Use with FastMCP client

import json

from fastmcp import Client

from biocontext_kb.core._server import core_mcp

async with Client(core_mcp) as client:
    tools = await client.list_tools()
    for tool in tools:
        print(f"Tool Name: {tool.name}")
        description = tool.description.replace("\n", " ")
        cleaned_description = " ".join(description.split())
        print(f"Tool Description: {cleaned_description}")
        print()

Tool Name: get_uniprot_id_by_protein_symbol
Tool Description: Query the UniProt database for the UniProt ID using the protein name. Args: protein_symbol (str): The name of the protein to search for (e.g., "SYNPO"). species (str): The organism ID (e.g., "9606" for human). Default is "9606". Returns: str: The UniProt ID of the protein. Raises: ValueError: If no results are found for the given protein name.

Tool Name: get_uniprot_protein_info
Tool Description: Query the UniProt database for protein information. Provide either protein_id or protein_name to search for a specific protein. Always provide the species parameter to ensure the correct protein is returned. Args: protein_id (str, optional): The protein identifier or accession number (e.g., "P04637"). Only provide if protein_name is None. protein_name (str, optional): The name of the protein to search for (e.g., "P53"). gene_symbol (str, optional): The gene name to search for (e.g., "TP53"). species (str, optional): Taxonomy ID (e.g., 10090) as string. include_references (bool, optional): Whether to include references and cross-references in the response. Defaults to False. Returns: dict: Protein data or error message

Tool Name: get_alphafold_info_by_protein_symbol
Tool Description: Query the AlphaFold database for the protein structure information using the protein name. This function constructs a query URL to fetch data from the AlphaFold database based on the provided protein name. The response contains links to the PDB and CIF files for the protein structure, as well as general information about the protein. Args: protein_symbol (Annotated[str, Field, optional): The name of the protein to search for (e.g., "SYNPO"). species (str): The organism ID (e.g., "9606" for human). Default is "9606". Returns: dict: Protein structure information or an error message.

Tool Name: get_antibody_information
Tool Description: Get detailed information for a specific antibody by its ID. This function retrieves comprehensive information about a single antibody from the Antibody Registry using its unique antibody ID (abId). The antibody ID is typically obtained from the results of get_antibody_list() function, where each antibody entry contains an 'abId' field that can be used with this function to get detailed information. Note: Some information provided by the Antibody Registry is for non-commercial use only. Users should refer to antibodyregistry.org for complete terms of use and licensing details. Args: ab_id (str): The unique antibody ID from the Antibody Registry. This is typically obtained from the 'abId' field in the results of get_antibody_list(), unless the ID is directly provided by the user. Returns: dict: Detailed antibody information including catalog number, vendor, clonality, epitope, applications, target species, isotype, source organism, citations, and other metadata, or error message if the request fails.

Tool Name: get_antibody_list
Tool Description: Query the Antibody Registry for available antibodies. This function searches the Antibody Registry database for antibodies matching the search term. Common search parameters include gene symbols (e.g., 'TRPC6'), protein names, UniProt IDs, or other relevant identifiers. Note: Some information provided by the Antibody Registry is for non-commercial use only. Users should refer to antibodyregistry.org for complete terms of use and licensing details. Args: search (str): Search term for antibodies. Can be a gene symbol, protein name, UniProt ID, or similar identifier. Returns: dict: Antibody search results including catalog numbers, vendor information, clonality, applications, and other antibody metadata, or error message if the request fails.

Tool Name: get_biorxiv_preprint_details
Tool Description: Get detailed information about a specific preprint by DOI. This tool retrieves detailed metadata for a single preprint from bioRxiv or medRxiv using its DOI identifier. Args: doi (str): DOI of the preprint (e.g., '10.1101/2020.09.09.20191205'). server (str): Server to search - 'biorxiv' or 'medrxiv' (default: 'biorxiv'). Returns: dict: Detailed preprint information or error message

Tool Name: get_recent_biorxiv_preprints
Tool Description: Get recent preprints from bioRxiv or medRxiv. This tool searches the bioRxiv and medRxiv preprint servers for research papers. You can search by date range, recent posts, or most recent papers. Results are paginated with up to 100 papers per API call. Args: server (str): Server to search - 'biorxiv' or 'medrxiv' (default: 'biorxiv'). start_date (str, optional): Start date in YYYY-MM-DD format. end_date (str, optional): End date in YYYY-MM-DD format. days (int, optional): Number of recent days to search (1-365). recent_count (int, optional): Number of most recent preprints (1-1000). category (str, optional): Subject category filter (e.g., 'cell biology', 'neuroscience'). cursor (int): Starting position for pagination (default: 0). max_results (int): Maximum number of results to return (default: 100, max: 500). Returns: dict: Preprint search results or error message

Tool Name: get_recruiting_studies_by_location
Tool Description: Find recruiting clinical trials in a specific geographic location. This function helps patients and healthcare providers find clinical trials that are currently recruiting participants in their area. Args: location_country (str): Country name where studies are conducted. location_state (str, optional): State or province name. location_city (str, optional): City name. condition (str, optional): Medical condition to filter by. study_type (str, optional): Type of study filter (default: "ALL"). age_range (str, optional): Age group filter (default: "ALL"). page_size (int): Number of results to return (default: 50, max: 1000). Returns: dict: Recruiting studies in the specified location or error message

Tool Name: get_studies_by_condition
Tool Description: Search for clinical trials by medical condition with simplified parameters. This function provides a focused search for clinical trials related to a specific medical condition, with common filters that biomedical researchers typically use. Args: condition (str): Medical condition or disease name to search for. status (str, optional): Study status filter (default: "ALL"). study_type (str, optional): Type of study filter (default: "ALL"). location_country (str, optional): Country where studies are conducted. page_size (int): Number of results to return (default: 50, max: 1000). sort (str): Sort order for results (default: most recently updated). Returns: dict: Study search results with summary statistics or error message

Tool Name: get_studies_by_intervention
Tool Description: Search for clinical trials by drug or intervention name. This function helps biomedical researchers find clinical trials testing specific drugs, therapies, or treatments, with optional filters for condition and phase. Args: intervention (str): Drug, therapy, or treatment name to search for. condition (str, optional): Medical condition to filter by. phase (str, optional): Clinical trial phase to filter by. status (str, optional): Study status filter (default: "ALL"). intervention_type (str, optional): Type of intervention filter (default: "ALL"). page_size (int): Number of results to return (default: 50, max: 1000). sort (str): Sort order for results (default: most recently updated). Returns: dict: Study search results with summary statistics or error message

Tool Name: get_study_details
Tool Description: Get detailed information about a specific clinical trial by its NCT ID. This function retrieves comprehensive data about a single clinical trial, including study design, eligibility criteria, outcomes, locations, and contact information. Args: nct_id (str): NCT ID of the clinical trial (e.g., "NCT01234567"). fields (str): Comma-separated list of fields to return, or "all" for complete data. Default includes key modules for biomedical researchers. Returns: dict: Detailed study information or error message

Tool Name: search_studies
Tool Description: Search for clinical trials studies based on various criteria. This function allows biomedical researchers to find relevant clinical trials by searching across conditions, interventions, sponsors, and other study characteristics. Args: condition (str, optional): Medical condition or disease to search for. intervention (str, optional): Drug, therapy, or treatment name to search for. sponsor (str, optional): Study sponsor organization. status (str, optional): Current status of the study. phase (str, optional): Clinical trial phase. study_type (str, optional): Type of study (interventional, observational, etc.). location_country (str, optional): Country where study is conducted. min_age (int, optional): Minimum age of participants in years. max_age (int, optional): Maximum age of participants in years. sex (str, optional): Sex of participants. page_size (int): Number of results to return (default: 25, max: 1000). sort (str): Sort order for results (default: most recently updated). Returns: dict: Study search results or error message

Tool Name: get_ensembl_id_from_gene_symbol
Tool Description: Query the Ensembl database for the Ensembl ID of a given gene name. Always provide the species parameter to ensure the correct protein is returned. Args: gene_symbol (str): The name of the gene to search for (e.g., "TP53"). species (str): Taxonomy ID (e.g., 10090) as string (default: "9606"). Returns: dict: Gene data or error message

Tool Name: get_europepmc_articles
Tool Description: Query the Europe PMC database for scientific articles. Use 'recent' sort for current research queries and 'cited' sort for comprehensive career overviews or well-established topics (e.g., "what has author X published on in their career"). Provide at least one of the following search parameters: - query: General search query string - title: Search term for article titles - abstract: Search term for article abstracts. - author: Author name (e.g., "last_name,first_name"). Should not contain spaces. These will be combined with the specified search type ("and" or "or"). For a broad search, prefer the "query" parameter and "or" search type. Only use the "and" search type if you want to ensure all terms must match. Args: query (str, optional): General search query string. title (str, optional): Search term for article titles. abstract (str, optional): Search term for article abstracts. author (str, optional): Author name (e.g., "last_name,first_name"). Should not contain spaces. search_type (str): Search type - "and" or "or" (default: "or"). sort_by (str): Sort by - "recent" for most recent, "cited" for most cited or None for no specific sorting (default: None). page_size (int): Number of results to return (default: 25, max: 1000). Returns: dict: Article search results or error message

Tool Name: get_europepmc_fulltext
Tool Description: Get the full text XML for a given PMC ID from Europe PMC. Args: pmc_id (str): PMC ID starting with "PMC" (e.g., "PMC11629965"). Returns: dict: Full text XML content or error message

Tool Name: search_grants_gov
Tool Description: Search for grants from grants.gov using the Search2 API. Args: keyword: Keyword to search for opp_num: Opportunity number eligibilities: Eligibility criteria (comma-separated) agencies: Agency codes (comma-separated) rows: Number of results to return opp_statuses: Opportunity statuses (pipe-separated, e.g. 'forecasted|posted') aln: Assistance Listing Number funding_categories: Funding categories (comma-separated) Returns: dict: Search results from grants.gov or error message

Tool Name: get_interpro_entry
Tool Description: Get detailed information about a specific InterPro entry. InterPro entries represent protein families, domains, and functional sites. Each entry integrates information from multiple member databases. Args: interpro_id (str): The InterPro entry identifier (e.g., "IPR000001"). include_interactions (bool, optional): Whether to include protein-protein interactions data. Defaults to False. include_pathways (bool, optional): Whether to include pathway information. Defaults to False. include_cross_references (bool, optional): Whether to include cross-references to other databases. Defaults to False. Returns: dict: InterPro entry data including description, type, member databases, and optional additional data

Tool Name: get_protein_domains
Tool Description: Get domain architecture and InterPro matches for a specific protein. This function retrieves all InterPro domain matches for a given protein, providing insight into the protein's functional domains and architecture. To get the protein's UniProt ID, use the `get_uniprot_id_by_protein_symbol` tool first. Args: protein_id (str): The protein identifier or accession (e.g., "P04637" or "CYC_HUMAN"). source_db (str, optional): The protein database source. Defaults to "uniprot". include_structure_info (bool, optional): Whether to include structural information. Defaults to False. species_filter (str, optional): Taxonomy ID to filter results (e.g., "9606" for human). Defaults to None. Returns: dict: Protein domain information including InterPro matches, domain architecture, and optional structural data

Tool Name: search_interpro_entries
Tool Description: Search InterPro entries by various criteria. This function allows searching the InterPro database using different filters such as entry type, source database, GO terms, and species. Args: query (str, optional): Search term for InterPro entry names or descriptions. entry_type (str, optional): Filter by entry type (family, domain, etc.). source_database (str, optional): Filter by member database (pfam, prosite, etc.). go_term (str, optional): Filter by GO term (e.g., "GO:0006122"). species_filter (str, optional): Filter by taxonomy ID (e.g., "9606" for human). page_size (int, optional): Number of results to return (max 200). Defaults to 20. Returns: dict: Search results with InterPro entries matching the criteria

Tool Name: get_available_ontologies
Tool Description: Query the Ontology Lookup Service (OLS) for all available ontologies. This function retrieves a list of all ontologies available in OLS, including their names, descriptions, and metadata. Use this function first to discover which ontologies are available before using other search functions. Returns: dict: Dictionary containing available ontologies and their information or error message

Tool Name: get_cell_ontology_terms
Tool Description: Query the Ontology Lookup Service (OLS) for Cell Ontology (CL) terms. This function searches for Cell Ontology terms associated with cell types using the OLS API. The Cell Ontology provides a controlled vocabulary for cell types. Args: cell_type (str): The cell type to search for (e.g., "T cell"). size (int): Maximum number of results to return (default: 10). exact_match (bool): Whether to perform an exact match search (default: False). Returns: dict: Dictionary containing Cell Ontology terms and information or error message

Tool Name: get_chebi_terms_by_chemical
Tool Description: Query the Ontology Lookup Service (OLS) for ChEBI terms related to a chemical name. This function searches for ChEBI (Chemical Entities of Biological Interest) terms associated with a given chemical name using the OLS API. Args: chemical_name (str): The chemical or drug name to search for (e.g., "aspirin"). size (int): Maximum number of results to return (default: 10). exact_match (bool): Whether to perform an exact match search (default: False). Returns: dict: Dictionary containing ChEBI terms and information or error message

Tool Name: get_efo_id_by_disease_name
Tool Description: Query the Ontology Lookup Service (OLS) for EFO/Mondo/HP IDs related to a disease name. This function searches for EFO IDs associated with a given disease name using the OLS API. Always use this function if you need EFO IDs, e.g., for use in the Open Targets API. Args: disease_name (str): The name of the disease to search for (e.g., "SIDS"). size (int): Maximum number of results to return (default: 5). exact_match (bool): Whether to perform an exact match search (default: False). Returns: dict: Dictionary containing EFO IDs and information or error message

Tool Name: get_go_terms_by_gene
Tool Description: Query the Ontology Lookup Service (OLS) for Gene Ontology (GO) terms related to a gene name. This function searches for GO terms associated with a given gene name using the OLS API. Gene Ontology provides structured vocabularies for gene and gene product attributes. Args: gene_name (str): The gene name or symbol to search for (e.g., "TP53"). size (int): Maximum number of results to return (default: 10). exact_match (bool): Whether to perform an exact match search (default: False). Returns: dict: Dictionary containing GO terms and information or error message

Tool Name: get_term_details
Tool Description: Query the Ontology Lookup Service (OLS) for detailed information about a specific term. This function retrieves comprehensive information about a specific ontology term, including its definition, synonyms, hierarchical relationships, and cross-references. Args: term_id (str): The term ID in CURIE format (e.g., "EFO:0000001"). ontology_id (str): The ontology ID (e.g., "efo"). Returns: dict: Dictionary containing detailed term information or error message

Tool Name: get_term_hierarchical_children
Tool Description: Query the Ontology Lookup Service (OLS) for hierarchical children of a term. This function retrieves the hierarchical children of a specific ontology term, including subclasses and terms related via hierarchical properties like 'part of'. Args: term_id (str): The term ID in CURIE format (e.g., "EFO:0000001"). ontology_id (str): The ontology ID (e.g., "efo"). size (int): Maximum number of children to return (default: 20). Returns: dict: Dictionary containing hierarchical children or error message

Tool Name: search_ontology_terms
Tool Description: Query the Ontology Lookup Service (OLS) for terms across multiple ontologies. This function provides a general search across ontologies in OLS, allowing you to find terms from multiple ontologies or search all ontologies at once. TIP: Use get_available_ontologies() first to discover which ontologies are available and their IDs before searching. Args: search_term (str): The term to search for. ontologies (str): Comma-separated ontology IDs (e.g., "efo,go,chebi"). Empty for all. Use get_available_ontologies() to see available options. size (int): Maximum number of results to return (default: 20). exact_match (bool): Whether to perform an exact match search (default: False). Returns: dict: Dictionary containing terms from various ontologies or error message

Tool Name: get_available_pharmacologic_classes
Tool Description: Get available pharmacologic classes from the FDA database. This function retrieves the actual pharmacologic class values available in the FDA database, which can then be used with search_drugs_by_therapeutic_class. Always call this function first to see available options before searching. Args: class_type (str): Type of classification - epc, moa, pe, or cs. limit (int): Maximum number of unique classes to return. Returns: dict: Available pharmacologic class values in the FDA database.

Tool Name: search_drugs_by_therapeutic_class
Tool Description: Search for drugs by their therapeutic or pharmacologic class. IMPORTANT: Use get_available_pharmacologic_classes() first to see the exact class terms available in the FDA database. This function requires exact matches of the pharmacologic class terms as they appear in the FDA data. Args: therapeutic_class (str): The exact therapeutic class term from FDA database. class_type (str): Type of classification - epc, moa, pe, or cs. limit (int): Maximum number of results to return. Returns: dict: Search results for drugs in the specified therapeutic class.

Tool Name: get_generic_equivalents
Tool Description: Find generic equivalents for a brand name drug. This function searches for ANDA (Abbreviated New Drug Application) entries that are generic equivalents of a specified brand name drug. Args: brand_name (str): The brand name drug to find generics for. Returns: dict: Generic drug equivalents and their manufacturers.

Tool Name: count_drugs_by_field
Tool Description: Count unique values in a specific field across FDA-approved drugs. This function is useful for statistical analysis and getting overviews of the drug database. Common fields to count include: - sponsor_name: Count drugs by pharmaceutical company - products.dosage_form: Count by dosage forms (tablet, injection, etc.) - products.route: Count by administration routes (oral, injection, etc.) - products.marketing_status: Count by marketing status - openfda.pharm_class_epc: Count by pharmacologic class Args: field (str): The field to count unique values for. search_filter (str, optional): Search filter to apply before counting. limit (int): Maximum number of count results to return. Returns: dict: Count results showing terms and their frequencies.

Tool Name: get_drug_statistics
Tool Description: Get general statistics about the FDA Drugs@FDA database. This function provides an overview of the database including: - Top pharmaceutical sponsors by number of approved drugs - Most common dosage forms - Most common routes of administration - Distribution of marketing statuses Returns: dict: Statistical overview of the FDA drugs database.

Tool Name: get_drug_by_application_number
Tool Description: Get detailed information about a specific FDA-approved drug by its application number. Application numbers follow the format: NDA, ANDA, or BLA followed by 6 digits. - NDA: New Drug Application (brand name drugs) - ANDA: Abbreviated New Drug Application (generic drugs) - BLA: Biologics License Application (biological products) Args: application_number (str): The FDA application number. Returns: dict: Detailed drug information from the FDA Drugs@FDA API.

Tool Name: get_drug_label_info
Tool Description: Get drug labeling information including active ingredients, dosage, and usage instructions. This function retrieves comprehensive drug label information from the FDA's drug labeling database, which includes detailed product information, active ingredients, dosage forms, and administration routes. Args: brand_name (str, optional): Brand name of the drug. generic_name (str, optional): Generic name of the drug. ndc (str, optional): National Drug Code number. Returns: dict: Drug labeling information from the FDA API.

Tool Name: search_drugs_fda
Tool Description: Search the FDA Drugs@FDA database for approved drug products. This function searches for FDA-approved drugs based on various criteria including brand names, generic names, active ingredients, sponsors, and regulatory information. Args: brand_name (str, optional): Brand or trade name of the drug. generic_name (str, optional): Generic name of the drug. active_ingredient (str, optional): Active ingredient name. sponsor_name (str, optional): Company or sponsor name. application_number (str, optional): FDA application number (NDA, ANDA, or BLA). marketing_status (str, optional): Marketing status of the drug. dosage_form (str, optional): Dosage form of the drug. route (str, optional): Route of administration. search_type (str): How to combine search terms - "and" or "or". sort_by (str, optional): Field to sort results by. limit (int): Maximum number of results to return (1-1000). skip (int): Number of results to skip for pagination (0-25000). Returns: dict: Search results from the FDA Drugs@FDA API.

Tool Name: get_open_targets_graphql_schema
Tool Description: Fetch the Open Targets GraphQL schema.

Tool Name: get_open_targets_query_examples
Tool Description: Get example GraphQL queries for the Open Targets API. Returns a dictionary of named example queries that can be used with the query_open_targets_graphql tool. These examples demonstrate common use cases for retrieving data about targets, diseases, drugs, and their associations.

Tool Name: query_open_targets_graphql
Tool Description: Execute a GraphQL query against the Open Targets API after fetching the schema. Important: Always first fetch examples using the schema using `get_open_targets_query_examples`. If the examples are not sufficient, also get the schema using the `get_open_targets_graphql_schema` tool before executing a query. Relying on either of these options provides the necessary context for the query and ensures that the query is valid. Queries should use the Ensembl gene ID (e.g., "ENSG00000141510"). If necessary, first use `get_ensembl_id_from_gene_symbol` to convert gene symbols (e.g., "TP53") to Ensembl IDs. If a disease ID is needed, use the `get_efo_id_from_disease_name` tool to get the EFO ID (e.g., "EFO_0004705") for a disease name (e.g., "Hypothyroidism"). Make sure to always start the query string with the keyword `query` followed by the query name. The query string should be a valid GraphQL query, and the variables should be a dictionary of parameters that the query requires. Open Targets provides data on: - target: annotations, tractability, mouse models, expression, disease/phenotype associations, available drugs. - disease: annotations, ontology, drugs, symptoms, target associations. - drug: annotations, mechanisms, indications, pharmacovigilance. - variant: annotations, frequencies, effects, consequences, credible sets. - studies: annotations, traits, publications, cohorts, credible sets. - credibleSet: annotations, variant sets, gene assignments, colocalization. - search: index of all platform entities. Args: query_string (str): The GraphQL query string. variables (dict): The variables for the GraphQL query. Returns: dict: The response data from the GraphQL API.

Tool Name: get_panglaodb_marker_genes
Tool Description: Retrieves marker genes from the PanglaoDB dataset based on specified filters. Args: species: The species ('Hs' for Human or 'Mm' for Mouse). min_sensitivity: Minimum sensitivity score (0-1). min_specificity: Minimum specificity score (0-1). organ: Filter by organ name (case-insensitive). cell_type: Filter by cell type name (case-insensitive). gene_symbol: Filter by gene symbol (case-insensitive). Returns: A dictionary containing a list of matching marker gene records or an error message.

Tool Name: get_panglaodb_options
Tool Description: Retrieves the available options for filtering marker genes in the PanglaoDB dataset. Returns: A dictionary containing lists of unique values for species, organ, cell type, and gene symbols.

Tool Name: get_pride_project
Tool Description: Get detailed information about a specific PRIDE project. PRIDE (PRoteomics IDEntifications) is a public repository for mass spectrometry proteomics data. This function retrieves comprehensive information about a specific project including metadata, experimental details, and optionally associated files and similar projects. Args: project_accession (str): The PRIDE project accession (e.g., "PRD000001"). include_files (bool, optional): Whether to include file information. Defaults to False. include_similar_projects (bool, optional): Whether to include similar projects. Defaults to False. Returns: dict: Project information including metadata, experimental details, and optional file/similar project data

Tool Name: search_pride_projects
Tool Description: Search PRIDE Archive projects by various criteria. This function searches the PRIDE database for mass spectrometry proteomics projects using keywords and filters. Useful for finding relevant datasets for comparative analysis or method validation. Args: keyword (str, optional): Search keywords for project titles/descriptions. organism_filter (str, optional): Filter by organism name. instrument_filter (str, optional): Filter by mass spectrometer instrument. experiment_type_filter (str, optional): Filter by experimental approach. page_size (int, optional): Number of results (max 100). Defaults to 20. sort_field (str, optional): Sort field. Defaults to "submissionDate". sort_direction (str, optional): Sort direction. Defaults to "DESC". Returns: dict: Search results with matching PRIDE projects and metadata

Tool Name: search_pride_proteins
Tool Description: Search proteins identified in a specific PRIDE project. This function searches for proteins identified in a specific PRIDE mass spectrometry project. Useful for finding specific proteins of interest in proteomics datasets. Args: project_accession (str): The PRIDE project accession to search in. keyword (str, optional): Search keyword for protein names or accessions. page_size (int, optional): Number of results (max 100). Defaults to 20. sort_field (str, optional): Sort field. Defaults to "accession". sort_direction (str, optional): Sort direction. Defaults to "ASC". Returns: dict: Search results with proteins found in the specified project

Tool Name: get_human_protein_atlas_info
Tool Description: Query the Human Protein Atlas API for target general information, genetic constraint, and tractability.

Tool Name: get_reactome_info_by_identifier
Tool Description: Query the Reactome API identifier endpoint. Use this endpoint to retrieve pathways associated with a given identifier. Always provide the species parameter to ensure the correct protein is returned. Args: identifier (str): The identifier of the element to be retrieved base_url (str): Base URL for the Reactome API interactors (bool): Include interactors species (str or list): List of species to filter the result (accepts taxonomy ids, species names and dbId) page_size (int): Pathways per page page (int): Page number sort_by (str): Field to sort results by (e.g., "ENTITIES_PVALUE", "ENTITIES_FDR") order (str): Sort order ("ASC" or "DESC") resource (str): Resource to filter by (TOTAL includes all molecule types) p_value (float): P-value threshold (only pathways with p-value <= threshold will be returned) include_disease (bool): Set to False to exclude disease pathways min_entities (int): Minimum number of contained entities per pathway max_entities (int): Maximum number of contained entities per pathway importable_only (bool): Filter to only include importable resources timeout (int): Request timeout in seconds Returns: dict: API response data or error information

Tool Name: get_string_id
Tool Description: Map a protein identifier to STRING database IDs. This function helps resolve common gene names, synonyms, or UniProt identifiers to the STRING-specific identifiers. Using STRING IDs in subsequent API calls improves reliability and performance. Args: protein_symbol (str): The name of the protein to search for (e.g., "TP53"). species (str): The species taxonomy ID (e.g., "9606" for human). Optional. return_field (str): The field to return. Either `stringId` or `preferredName` (default: stringId). limit (int): Limit the number of matches returned per query (default: 1). Returns: str: The STRING ID or preferred name if found, otherwise an error message.

Tool Name: get_string_interactions
Tool Description: Get all protein-protein interactions for a given protein with a combined score above the threshold. Always provide the species parameter to ensure the correct protein is returned. Args: protein_symbol (str): The name of the protein to search for (e.g., "TP53"). species (str): The species taxonomy ID (e.g., "10090" for mouse). min_score (int): Minimum combined score threshold (default: 700). Returns: list: A list of dictionaries containing interacting proteins and their scores.

Tool Name: get_string_network_image
Tool Description: Get a network image for a given protein from the STRING database. Always provide the species parameter to ensure the correct protein is returned. Args: protein_symbol (str): The name of the protein to search for (e.g., "TP53"). species (str): The species taxonomy ID (e.g., "10090" for mouse). flavor (str): The network flavor to use (default: "confidence"). min_score (int): Minimum combined score threshold (default: 700). Returns: Image: The network image for the protein.

Tool Name: get_string_similarity_scores
Tool Description: Get similarity scores between proteins from the STRING database. The scores represent protein homology based on Smith-Waterman bit scores. Only scores above 50 are reported, and only half of the similarity matrix (since it's symmetric) plus self-hits are returned. Args: protein_symbol (str): The protein symbol of the first protein (e.g., "TP53"). protein_symbol_comparison (str): The protein symbol of the second protein (e.g., "MKI67"). species (str): The species taxonomy ID (e.g., "9606" for human). Optional. Returns: list: A list of dictionaries containing protein pairs and their bit scores.

Tool Name: get_kegg_id_by_gene_symbol
Tool Description: Get KEGG ID by gene symbol. This function converts a gene symbol (like TP53) to a KEGG gene ID (like hsa:7157) for use in the KEGG API. The KEGG API typically requires KEGG IDs rather than gene symbols for most operations. This is often the first step in a workflow - get the KEGG ID, then use it in subsequent API calls. Common organism codes: - Human: 9606 (KEGG code: hsa) - Mouse: 10090 (KEGG code: mmu) - Rat: 10116 (KEGG code: rno) - E. coli: 562 (KEGG code: eco) - Yeast: 4932 (KEGG code: sce) Args: gene_symbol (str): The gene symbol to search for (e.g., "TP53" for human, "Trp53" for mouse). organism_code (str): The organism code as taxonomy ID (e.g., "9606" for human, "10090" for mouse). Returns: str | dict: The KEGG ID (e.g., "hsa:7157") or an error message. Examples: >>> get_kegg_id_by_gene_symbol(gene_symbol="TP53", organism_code="9606") "hsa:7157" >>> get_kegg_id_by_gene_symbol(gene_symbol="Trp53", organism_code="10090") "mmu:22059"

Tool Name: query_kegg
Tool Description: Execute a KEGG API query. This function provides access to the KEGG API, allowing you to query biological data across pathways, genes, compounds, diseases, and more. The function can perform all KEGG API operations and accepts various parameters depending on the operation. When searching for genes in KEGG, you typically need KEGG IDs rather than gene symbols. Use the get_kegg_id_by_gene_symbol function first to convert gene symbols to KEGG IDs. Common operations: - info: Get database metadata (e.g., operation=info, database=PATHWAY) - list: List entries in a database (e.g., operation=list, database=PATHWAY, query="hsa") - get: Retrieve specific entries (e.g., operation=get, entries=["hsa:7157"]) - find: Search for entries by keyword (e.g., operation=find, database=COMPOUND, query="glucose") - link: Find related entries (e.g., operation=link, target_db=PATHWAY, entries=["hsa:7157"]) - conv: Convert between identifiers (e.g., operation=conv, target_db=NCBI_GENEID, entries=["hsa:7157"]) Args: operation (KeggOperation): The KEGG operation to perform. database (KeggDatabase | KeggOutsideDb | str, optional): The database to query. target_db (KeggDatabase | KeggOutsideDb | str, optional): The target database for conversion. source_db (KeggDatabase | KeggOutsideDb | str, optional): The source database for conversion. query (str, optional): The query string for FIND or LIST operations. option (KeggOption | KeggFindOption | KeggRdfFormat, optional): Additional options for the operation. entries (List[str], optional): List of entries for GET or LINK operations. Returns: str | dict: The result of the KEGG query or an error message. Examples: # List human pathways >>> query_kegg(operation=KeggOperation.LIST, database=KeggDatabase.PATHWAY, query="hsa") # Get data for the glycolysis pathway >>> query_kegg(operation=KeggOperation.GET, entries=["hsa00010"]) # Get data for the TP53 gene >>> query_kegg(operation=KeggOperation.GET, entries=["hsa:7157"]) # Get amino acid sequence for TP53 >>> query_kegg(operation=KeggOperation.GET, entries=["hsa:7157"], option=KeggOption.AASEQ) # Find compounds with formula C7H10O5 >>> query_kegg(operation=KeggOperation.FIND, database=KeggDatabase.COMPOUND, query="C7H10O5", option="formula") # Find pathways related to TP53 >>> query_kegg(operation=KeggOperation.LINK, target_db=KeggDatabase.PATHWAY, entries=["hsa:7157"]) # Convert KEGG ID to NCBI Gene ID >>> query_kegg(operation=KeggOperation.CONV, target_db="ncbi-geneid", source_db="hsa:7157") # Get information about a specific pathway >>> query_kegg(operation=KeggOperation.GET, entries=["hsa00010"]) # Get the compound ID for caffeine >>> query_kegg(operation=KeggOperation.FIND, database=KeggDatabase.COMPOUND, query="caffeine") # Get the drug ID for acetaminophen >>> query_kegg(operation=KeggOperation.FIND, database=KeggDatabase.DRUG, query="acetaminophen") # Check if two drugs interact (ibuprofen and aspirin) >>> query_kegg(operation=KeggOperation.DDI, entries=["dr:D00126", "dr:D00109"])

Tool Name: search_google_scholar_publications
Tool Description: Search for publications on Google Scholar. Supports advanced search operators including author search using 'author:"Name"' syntax. Examples: - 'machine learning' - General topic search - 'author:"John Smith"' - Publications by specific author - 'author:"John Smith" neural networks' - Author's work on specific topic WARNING: Google Scholar may block requests and IP addresses for excessive queries. Publication searches are particularly prone to triggering anti-bot measures. This tool automatically uses free proxies to mitigate blocking, but use responsibly. For academic research, consider using alternative databases like PubMed/EuropePMC when possible to reduce load on Google Scholar. Args: query (str): Search query for publications. Use 'author:"Name"' to search by author. max_results (int): Maximum number of publications to return (default: 10, max: 50). use_proxy (bool): Whether to use free proxies to avoid rate limiting (default: True). Returns: dict: Publication search results or error message

async with Client(core_mcp) as client:
    result_text = await client.call_tool(
        "get_uniprot_protein_info", {"protein_id": None, "gene_symbol": "P53", "species": "9606"}
    )
    result = json.loads(result_text.content[0].text)
    print(result)

{'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'P04637', 'secondaryAccessions': ['Q15086', 'Q15087', 'Q15088', 'Q16535', 'Q16807', 'Q16808', 'Q16809', 'Q16810', 'Q16811', 'Q16848', 'Q2XN98', 'Q3LRW1', 'Q3LRW2', 'Q3LRW3', 'Q3LRW4', 'Q3LRW5', 'Q86UG1', 'Q8J016', 'Q99659', 'Q9BTM4', 'Q9HAQ8', 'Q9NP68', 'Q9NPJ2', 'Q9NZD0', 'Q9UBI2', 'Q9UQ61'], 'uniProtkbId': 'P53_HUMAN', 'entryAudit': {'firstPublicDate': '1987-08-13', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '2009-11-24', 'entryVersion': 312, 'sequenceVersion': 4}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Cellular tumor antigen p53'}}, 'alternativeNames': [{'fullName': {'value': 'Antigen NY-CO-13'}}, {'fullName': {'value': 'Phosphoprotein p53'}}, {'fullName': {'value': 'Tumor suppressor p53'}}]}, 'genes': [{'geneName': {'value': 'TP53'}, 'synonyms': [{'value': 'P53'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11025664'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12524540'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15186775'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15340061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17189187'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17317671'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17349958'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19556538'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20673990'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22726440'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24051492'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24652652'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '35618207'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36634798'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '38653238'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9840937'}], 'value': 'Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)'}], 'commentType': 'FUNCTION'}, {'commentType': 'COFACTOR', 'cofactors': [{'name': 'Zn(2+)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}], 'cofactorCrossReference': {'database': 'ChEBI', 'id': 'CHEBI:29105'}}], 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}], 'value': 'Binds 1 zinc ion per subunit.'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P02340'}, {'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P10361'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12524540'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12750254'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12851404'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14702041'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15053879'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15109303'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15136035'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15186775'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15687255'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15855171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16219768'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16322561'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16376338'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16377624'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16402859'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16474402'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16845383'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108107'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17121812'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17145718'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17170702'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17245430'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17317671'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17332504'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17719541'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17904127'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17954561'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17967874'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18585004'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18690848'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18996393'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19509332'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19536131'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19556538'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19837670'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19880522'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20096117'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20124405'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20228809'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20385133'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20660729'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20870725'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21317932'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21952639'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22214662'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22522597'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22726440'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22945289'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23431171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23752197'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24625977'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25168243'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25422469'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25732823'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26868148'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '27323408'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28842590'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29681526'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '32442400'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '33591310'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '34404770'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '35122041'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8875926'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8875929'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9840937'}], 'value': "Forms homodimers and homotetramers (PubMed:19011621). Binds DNA as a homotetramer (PubMed:36108750). Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3 (PubMed:17332504). Interacts (via C-terminus) with POU4F2 isoform 1 (via C-terminus) (PubMed:17145718). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53 (PubMed:22522597). Interacts with AFG1L; mediates mitochondrial translocation of TP53 (PubMed:27323408). Interacts with UBD (PubMed:25422469). Interacts with TAF6 isoform 1 and isoform 4 (PubMed:20096117). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent (PubMed:18690848). Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (PubMed:19011621). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (PubMed:12524540). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (PubMed:12524540). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (PubMed:28842590). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (PubMed:17954561). Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation (PubMed:21597459). Interacts with S100A4; this interaction promotes TP53 degradation (PubMed:23752197, PubMed:32442400). Interacts with BANP (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (PubMed:25168243). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (PubMed:33591310). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (PubMed:34404770). Forms a ternary complex with ALDOB and G6PD; this interaction is direct. ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check. Interacts with MORN3; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 (PubMed:29681526). Interacts with HSPA9/MOT-2; the interaction promotes the degradation of TP53 (PubMed:24625977). Interacts with FBXO22; this interaction promotes TP53 proteasomal degradation (PubMed:26868148)"}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2175676'}], 'value': '(Microbial infection) Interacts with cancer-associated/HPV E6 viral proteins leading to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6'}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19776115'}], 'value': '(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123'}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25772236'}], 'value': '(Microbial infection) Interacts (via N-terminus) with human adenovirus 5 E1B-55K protein; this interaction leads to the inhibition of TP53 function and/or its degradation'}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '34523970'}], 'value': "(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction results in the cytoplasmic localization of TP53 thereby decreasing its transcriptional activity"}], 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{'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P03126', 'geneName': 'E6', 'intActId': 'EBI-1177242'}, 'numberOfExperiments': 5, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P06463', 'geneName': 'E6', 'intActId': 'EBI-1186926'}, 'numberOfExperiments': 3, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P02829', 'geneName': 'HSP82', 'intActId': 'EBI-8659'}, 'numberOfExperiments': 8, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'Q08619', 'geneName': 'Ifi205b', 'intActId': 'EBI-8064290'}, 'numberOfExperiments': 2, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P89055', 'geneName': 'NSP1', 'intActId': 'EBI-9522973'}, 'numberOfExperiments': 6, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'Q923E4', 'geneName': 'Sirt1', 'intActId': 'EBI-1802585'}, 'numberOfExperiments': 4, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'Q8R5A0', 'geneName': 'Smyd2', 'intActId': 'EBI-15612527'}, 'numberOfExperiments': 3, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P32776', 'geneName': 'TFB1', 'intActId': 'EBI-19146'}, 'numberOfExperiments': 7, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'O88898', 'geneName': 'Tp63', 'intActId': 'EBI-2338025'}, 'numberOfExperiments': 2, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P26687', 'geneName': 'Twist1', 'intActId': 'EBI-6123119'}, 'numberOfExperiments': 4, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'Q9PST7', 'geneName': 'znf585b.S', 'intActId': 'EBI-1782562'}, 'numberOfExperiments': 3, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P03070', 'intActId': 'EBI-617698'}, 'numberOfExperiments': 22, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'P26663', 'chainId': 'PRO_0000037536', 'intActId': 'EBI-6838571'}, 'numberOfExperiments': 9, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637', 'intActId': 'EBI-366083'}, 'interactantTwo': {'uniProtKBAccession': 'Q8QW27', 'intActId': 'EBI-6863726'}, 'numberOfExperiments': 2, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P04637-1', 'intActId': 'EBI-3895849'}, 'interactantTwo': {'uniProtKBAccession': 'P17844', 'geneName': 'DDX5', 'intActId': 'EBI-351962'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P04637-7', 'intActId': 'EBI-3895873'}, 'interactantTwo': {'uniProtKBAccession': 'P17844', 'geneName': 'DDX5', 'intActId': 'EBI-351962'}, 'numberOfExperiments': 2, 'organismDiffer': False}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22726440'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24625977'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '27323408'}], 'value': 'Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). Competitive inhibition of TP53 interaction with HSPA9/MOT-2 by UBXN2A results in increased protein abundance and subsequent translocation of TP53 to the nucleus (PubMed:24625977)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15340061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17170702'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19033443'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21597459'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22726440'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24625977'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26634371'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15340061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17170702'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18206965'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21597459'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24625977'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26634371'}], 'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11025664'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}], 'value': 'Nucleus, PML body', 'id': 'SL-0465'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17170702'}], 'value': 'Endoplasmic reticulum', 'id': 'SL-0095'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22726440'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25168243'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '27323408'}], 'value': 'Mitochondrion matrix', 'id': 'SL-0170'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28842590'}], 'value': 'Cytoplasm, cytoskeleton, microtubule organizing center, centrosome', 'id': 'SL-0048'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 1', 'note': {'texts': [{'value': 'Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23752197'}], 'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 2', 'note': {'texts': [{'value': 'Localized mainly in the nucleus with minor staining in the cytoplasm'}]}, 'subcellularLocations': [{'location': {'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 3', 'note': {'texts': [{'value': 'Localized in the nucleus in most cells but found in the cytoplasm in some cells'}]}, 'subcellularLocations': [{'location': {'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 4', 'note': {'texts': [{'value': 'Predominantly nuclear but translocates to the cytoplasm following cell stress'}]}, 'subcellularLocations': [{'location': {'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 7', 'note': {'texts': [{'value': 'Localized mainly in the nucleus with minor staining in the cytoplasm'}]}, 'subcellularLocations': [{'location': {'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 8', 'note': {'texts': [{'value': 'Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli'}]}, 'subcellularLocations': [{'location': {'value': 'Nucleus', 'id': 'SL-0191'}}, {'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 9', 'subcellularLocations': [{'location': {'value': 'Cytoplasm', 'id': 'SL-0086'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative promoter usage', 'Alternative splicing'], 'isoforms': [{'name': {'value': '1'}, 'synonyms': [{'value': 'p53'}, {'value': 'p53alpha'}], 'isoformIds': ['P04637-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': '2'}, 'synonyms': [{'value': 'I9RET'}, {'value': 'p53beta'}], 'isoformIds': ['P04637-2'], 'sequenceIds': ['VSP_006535', 'VSP_006536'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '3'}, 'synonyms': [{'value': 'p53gamma'}], 'isoformIds': ['P04637-3'], 'sequenceIds': ['VSP_040560', 'VSP_040561'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '4'}, 'synonyms': [{'value': 'Del40-p53'}, {'value': 'Del40-p53alpha'}, {'value': 'p47'}], 'isoformIds': ['P04637-4'], 'sequenceIds': ['VSP_040832'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '5'}, 'synonyms': [{'value': 'Del40-p53beta'}], 'isoformIds': ['P04637-5'], 'sequenceIds': ['VSP_040832', 'VSP_006535', 'VSP_006536'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '6'}, 'synonyms': [{'value': 'Del40-p53gamma'}], 'isoformIds': ['P04637-6'], 'sequenceIds': ['VSP_040832', 'VSP_040560', 'VSP_040561'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '7'}, 'synonyms': [{'value': 'Del133-p53'}, {'value': 'Del133-p53alpha'}], 'isoformIds': ['P04637-7'], 'sequenceIds': ['VSP_040833'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '8'}, 'synonyms': [{'value': 'Del133-p53beta'}], 'isoformIds': ['P04637-8'], 'sequenceIds': ['VSP_040833', 'VSP_006535', 'VSP_006536'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '9'}, 'synonyms': [{'value': 'Del133-p53gamma'}], 'isoformIds': ['P04637-9'], 'sequenceIds': ['VSP_040833', 'VSP_040560', 'VSP_040561'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16131611'}], 'value': 'Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine'}], 'commentType': 'TISSUE SPECIFICITY'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16131611'}], 'value': 'Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress'}], 'commentType': 'INDUCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '31953488'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '35618207'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36634798'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '38653238'}], 'value': 'The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation (PubMed:31953488, PubMed:35618207, PubMed:36108750, PubMed:36634798, PubMed:38653238). Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS (PubMed:31953488, PubMed:35618207, PubMed:36634798, PubMed:38653238)'}], 'commentType': 'DOMAIN'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17467953'}], 'value': 'The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors'}], 'commentType': 'DOMAIN'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10656795'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15448695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17189187'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19854137'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20228809'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23431171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29474172'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29681526'}], 'value': 'Acetylation of Lys-382 by CREBBP enhances transcriptional activity (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Acetylation of Lys-382 by EP300 (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171, PubMed:29681526). Acetylation at Lys-381 increases stability (PubMed:29474172). Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence (PubMed:29474172). Acetylated at Lys-120 by KAT5, KAT6A and KAT8; regulating its ability to induce proapoptotic program (PubMed:17189187, PubMed:19854137, PubMed:23431171)'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '38653238'}], 'value': 'Lactylation by AARS1 prevents ability to undergo liquid-liquid phase separation (LLPS), thereby inhibiting transcription factor activity'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10606744'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10951572'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11239457'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11447225'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11546806'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11551930'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11554766'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11740489'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11780126'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14702041'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15053879'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15866171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16377624'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16704422'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1705009'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108107'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17254968'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17349958'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17967874'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18022393'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20041275'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20124405'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21317932'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2141171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22214662'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28842590'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '31527692'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9372954'}], 'value': 'Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage. Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (PubMed:28842590). Phosphorylation at Ser-392 regulates its ability to undergo liquid-liquid phase separation by increasing fluidity of TP53/p53 condensates (PubMed:35618207)'}], 'commentType': 'PTM'}, {'texts': [{'value': 'Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8632915'}], 'value': 'May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P02340'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10722742'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15053880'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15340061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17170702'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18206965'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19033443'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19473992'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19536131'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19556538'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19837670'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19880522'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20096447'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20173098'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21597459'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25591766'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25732823'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26868148'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28807825'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29681526'}], 'value': "Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation (PubMed:10722742, PubMed:12810724, PubMed:15340061, PubMed:17170702, PubMed:19880522, PubMed:29681526). Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:10722742, PubMed:12810724, PubMed:20173098). Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation (PubMed:19536131). Deubiquitinated by USP10, leading to its stabilization (PubMed:20096447). Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation (PubMed:19556538). Ubiquitination by TOPORS induces degradation (PubMed:19473992). Deubiquitination by USP7, leading to stabilization (PubMed:15053880). Isoform 4 is monoubiquitinated in an MDM2-independent manner (PubMed:15340061). Ubiquitinated by COP1, which leads to proteasomal degradation (PubMed:19837670). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (PubMed:25732823). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (PubMed:21597459). Deubiquitinated by USP3, leading to stabilization (PubMed:28807825). Ubiquitinated by MSL2, promoting its cytoplasmic localization (PubMed:19033443). Also ubiquitinated by the SCF(FBXO22)-KDMA4A complex; leading to proteasomal degradation (PubMed:26868148)"}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15525938'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16415881'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108971'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17707234'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17805299'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20118233'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22864287'}], 'value': 'Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation (PubMed:15525938, PubMed:16415881). Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity (PubMed:17108971). Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370 (PubMed:17108971). Dimethylated at Lys-373 by EHMT1 and EHMT2 (PubMed:20118233). Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity (PubMed:17707234). Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20 (PubMed:22864287). Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (PubMed:17805299). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (PubMed:19011621)'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11124955'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22214662'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.37'}], 'value': 'Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9'}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'note': {'texts': [{'value': 'TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Esophageal cancer', 'diseaseAccession': 'DI-01537', 'acronym': 'ESCR', 'description': 'A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.', 'diseaseCrossReference': {'database': 'MIM', 'id': '133239'}}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Li-Fraumeni syndrome', 'diseaseAccession': 'DI-01904', 'acronym': 'LFS', 'description': 'An autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.', 'diseaseCrossReference': {'database': 'MIM', 'id': '151623'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10484981'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1565144'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1737852'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1933902'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1978757'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2259385'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7887414'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8825920'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9452042'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Squamous cell carcinoma of the head and neck', 'diseaseAccession': 'DI-01696', 'acronym': 'HNSCC', 'description': 'A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.', 'diseaseCrossReference': {'database': 'MIM', 'id': '275355'}}, 'note': {'texts': [{'value': 'The gene represented in this entry is involved in disease pathogenesis'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Lung cancer', 'diseaseAccession': 'DI-02205', 'acronym': 'LNCR', 'description': 'A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.', 'diseaseCrossReference': {'database': 'MIM', 'id': '211980'}}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Papilloma of choroid plexus', 'diseaseAccession': 'DI-01346', 'acronym': 'CPP', 'description': 'A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures.', 'diseaseCrossReference': {'database': 'MIM', 'id': '260500'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12085209'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Adrenocortical carcinoma', 'diseaseAccession': 'DI-02740', 'acronym': 'ADCC', 'description': 'A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome.', 'diseaseCrossReference': {'database': 'MIM', 'id': '202300'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11481490'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Basal cell carcinoma 7', 'diseaseAccession': 'DI-03503', 'acronym': 'BCC7', 'description': 'A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.', 'diseaseCrossReference': {'database': 'MIM', 'id': '614740'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21946351'}]}, 'note': {'texts': [{'value': 'Disease susceptibility is associated with variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Bone marrow failure syndrome 5', 'diseaseAccession': 'DI-05371', 'acronym': 'BMFS5', 'description': 'A form of bone marrow failure syndrome, a heterogeneous group of life-threatening disorders characterized by hematopoietic defects in association with a range of variable extra-hematopoietic manifestations. BMFS5 is an autosomal dominant form characterized by infantile onset of severe red cell anemia requiring transfusion. Additional features include hypogammaglobulinemia, poor growth with microcephaly, developmental delay, and seizures.', 'diseaseCrossReference': {'database': 'MIM', 'id': '618165'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30146126'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay'}], 'commentType': 'MISCELLANEOUS', 'molecule': 'Isoform 2'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay'}], 'commentType': 'MISCELLANEOUS', 'molecule': 'Isoform 3'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Produced by alternative promoter usage'}], 'commentType': 'MISCELLANEOUS', 'molecule': 'Isoform 7'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Produced by alternative promoter usage and alternative splicing'}], 'commentType': 'MISCELLANEOUS', 'molecule': 'Isoform 8'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Produced by alternative promoter usage and alternative splicing'}], 'commentType': 'MISCELLANEOUS', 'molecule': 'Isoform 9'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the p53 family'}], 'commentType': 'SIMILARITY'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P02340'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11554766'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15340061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15701641'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15866171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16219768'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17170702'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17317671'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17954561'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18206965'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21597459'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22726440'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25772236'}, {'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '32144153'}], 'value': 'Interaction with BANP was reported to enhance phosphorylation on Ser-15 upon ultraviolet irradiation (PubMed:15701641). However, the publication has been retracted due to image duplication and manipulation. Interaction with BANP has been confirmed in mouse studies (By similarity). Phosphorylation at Ser-15 has been confirmed by other studies (PubMed:10570149, PubMed:11554766, PubMed:15866171, PubMed:16219768, PubMed:17317671, PubMed:17954561, PubMed:20959462, PubMed:25772236). Its nuclear and cytoplasmic localization has been confirmed by other studies (PubMed:15340061, PubMed:17170702, PubMed:17591690, PubMed:18206965, PubMed:19011621, PubMed:21597459, PubMed:22726440)'}], 'commentType': 'CAUTION'}, {'commentType': 'WEB RESOURCE', 'resourceName': 'The TP53 Database', 'resourceUrl': 'https://tp53.cancer.gov/', 'ftp': False}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Atlas of Genetics and Cytogenetics in Oncology and Haematology', 'resourceUrl': 'https://atlasgeneticsoncology.org/gene/88/P53', 'ftp': False}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Wikipedia', 'resourceUrl': 'https://en.wikipedia.org/wiki/P53', 'ftp': False, 'note': 'P53 entry'}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Protein Spotlight', 'resourceUrl': 'https://www.proteinspotlight.org/back_issues/206/', 'ftp': False, 'note': 'On the right track - Issue 206 of August 2018'}], 'features': [{'type': 'Chain', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'Cellular tumor antigen p53', 'featureId': 'PRO_0000185703'}, {'type': 'DNA binding', 'location': {'start': {'value': 102, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18996393'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}]}, {'type': 'Region', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 320, 'modifier': 'EXACT'}}, 'description': 'Interaction with CCAR2', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25732823'}]}, {'type': 'Region', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 83, 'modifier': 'EXACT'}}, 'description': 'Interaction with HRMT1L2', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15186775'}]}, {'type': 'Region', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'Transcription activation (acidic)'}, {'type': 'Region', 'location': {'start': {'value': 50, 'modifier': 'EXACT'}, 'end': {'value': 96, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '31953488'}]}, {'type': 'Region', 'location': {'start': {'value': 66, 'modifier': 'EXACT'}, 'end': {'value': 110, 'modifier': 'EXACT'}}, 'description': 'Interaction with WWOX'}, {'type': 'Region', 'location': {'start': {'value': 100, 'modifier': 'EXACT'}, 'end': {'value': 370, 'modifier': 'EXACT'}}, 'description': 'Interaction with HIPK1', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Region', 'location': {'start': {'value': 100, 'modifier': 'EXACT'}, 'end': {'value': 300, 'modifier': 'EXACT'}}, 'description': 'Required for interaction with ZNF385A', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17719541'}]}, {'type': 'Region', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 236, 'modifier': 'EXACT'}}, 'description': 'Required for interaction with FBXO42', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19509332'}]}, {'type': 'Region', 'location': {'start': {'value': 116, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': 'Interaction with AXIN1', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Region', 'location': {'start': {'value': 241, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'Interaction with the 53BP2 SH3 domain'}, {'type': 'Region', 'location': {'start': {'value': 256, 'modifier': 'EXACT'}, 'end': {'value': 294, 'modifier': 'EXACT'}}, 'description': 'Interaction with E4F1', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10644996'}]}, {'type': 'Region', 'location': {'start': {'value': 273, 'modifier': 'EXACT'}, 'end': {'value': 280, 'modifier': 'EXACT'}}, 'description': 'Interaction with DNA'}, {'type': 'Region', 'location': {'start': {'value': 282, 'modifier': 'EXACT'}, 'end': {'value': 325, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Region', 'location': {'start': {'value': 300, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'Interaction with CARM1', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15186775'}]}, {'type': 'Region', 'location': {'start': {'value': 319, 'modifier': 'EXACT'}, 'end': {'value': 360, 'modifier': 'EXACT'}}, 'description': 'Interaction with HIPK2'}, {'type': 'Region', 'location': {'start': {'value': 325, 'modifier': 'EXACT'}, 'end': {'value': 356, 'modifier': 'EXACT'}}, 'description': 'Oligomerization'}, {'type': 'Region', 'location': {'start': {'value': 351, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '31953488'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}]}, {'type': 'Region', 'location': {'start': {'value': 359, 'modifier': 'EXACT'}, 'end': {'value': 363, 'modifier': 'EXACT'}}, 'description': 'Interaction with USP7'}, {'type': 'Region', 'location': {'start': {'value': 368, 'modifier': 'EXACT'}, 'end': {'value': 387, 'modifier': 'EXACT'}}, 'description': 'Basic (repression of DNA-binding)'}, {'type': 'Region', 'location': {'start': {'value': 374, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'Interaction with MORN3', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29681526'}]}, {'type': 'Motif', 'location': {'start': {'value': 17, 'modifier': 'EXACT'}, 'end': {'value': 25, 'modifier': 'EXACT'}}, 'description': 'TADI'}, {'type': 'Motif', 'location': {'start': {'value': 48, 'modifier': 'EXACT'}, 'end': {'value': 56, 'modifier': 'EXACT'}}, 'description': 'TADII'}, {'type': 'Motif', 'location': {'start': {'value': 305, 'modifier': 'EXACT'}, 'end': {'value': 321, 'modifier': 'EXACT'}}, 'description': 'Bipartite nuclear localization signal'}, {'type': 'Motif', 'location': {'start': {'value': 339, 'modifier': 'EXACT'}, 'end': {'value': 350, 'modifier': 'EXACT'}}, 'description': 'Nuclear export signal'}, {'type': 'Motif', 'location': {'start': {'value': 370, 'modifier': 'EXACT'}, 'end': {'value': 372, 'modifier': 'EXACT'}}, 'description': '[KR]-[STA]-K motif'}, {'type': 'Compositional bias', 'location': {'start': {'value': 69, 'modifier': 'EXACT'}, 'end': {'value': 90, 'modifier': 'EXACT'}}, 'description': 'Pro residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 282, 'modifier': 'EXACT'}, 'end': {'value': 299, 'modifier': 'EXACT'}}, 'description': 'Basic and acidic residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 365, 'modifier': 'EXACT'}, 'end': {'value': 384, 'modifier': 'EXACT'}}, 'description': 'Basic residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 238, 'modifier': 'EXACT'}, 'end': {'value': 238, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 242, 'modifier': 'EXACT'}, 'end': {'value': 242, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14534297'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17015838'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18650397'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19515728'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20142040'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Site', 'location': {'start': {'value': 120, 'modifier': 'EXACT'}, 'end': {'value': 120, 'modifier': 'EXACT'}}, 'description': 'Interaction with DNA', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16793544'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18996393'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20364130'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 9, 'modifier': 'EXACT'}, 'end': {'value': 9, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by HIPK4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18022393'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 15, 'modifier': 'EXACT'}, 'end': {'value': 15, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11554766'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15866171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108107'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17967874'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21317932'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28842590'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 18, 'modifier': 'EXACT'}, 'end': {'value': 18, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CK1, VRK1 and VRK2', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10606744'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10951572'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16704422'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '31527692'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 20, 'modifier': 'EXACT'}, 'end': {'value': 20, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CHEK2, CK1 and PLK3', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11447225'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11551930'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12810724'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20041275'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CDK5 and CDK7', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9372954'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 37, 'modifier': 'EXACT'}, 'end': {'value': 37, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by MAPKAPK5', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17254968'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 46, 'modifier': 'EXACT'}, 'end': {'value': 46, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11740489'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11780126'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16377624'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17349958'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17591690'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 55, 'modifier': 'EXACT'}, 'end': {'value': 55, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by TAF1 and GRK5', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15053879'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20124405'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 120, 'modifier': 'EXACT'}, 'end': {'value': 120, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17189187'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19854137'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23431171'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 120, 'modifier': 'EXACT'}, 'end': {'value': 120, 'modifier': 'EXACT'}}, 'description': 'N6-lactoyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '38653238'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 139, 'modifier': 'EXACT'}, 'end': {'value': 139, 'modifier': 'EXACT'}}, 'description': 'N6-lactoyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '38653238'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 183, 'modifier': 'EXACT'}, 'end': {'value': 183, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by AURKB', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 269, 'modifier': 'EXACT'}, 'end': {'value': 269, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by AURKB', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 284, 'modifier': 'EXACT'}, 'end': {'value': 284, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by AURKB', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 305, 'modifier': 'EXACT'}, 'end': {'value': 305, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12724314'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 315, 'modifier': 'EXACT'}, 'end': {'value': 315, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by AURKA, CDK1 and CDK2', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14702041'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 321, 'modifier': 'EXACT'}, 'end': {'value': 321, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P02340'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 333, 'modifier': 'EXACT'}, 'end': {'value': 333, 'modifier': 'EXACT'}}, 'description': 'Omega-N-methylarginine; by PRMT5', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 335, 'modifier': 'EXACT'}, 'end': {'value': 335, 'modifier': 'EXACT'}}, 'description': 'Symmetric dimethylarginine; by PRMT5', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'Symmetric dimethylarginine; by PRMT5', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 370, 'modifier': 'EXACT'}, 'end': {'value': 370, 'modifier': 'EXACT'}}, 'description': 'N6,N6-dimethyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108971'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22864287'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 370, 'modifier': 'EXACT'}, 'end': {'value': 370, 'modifier': 'EXACT'}}, 'description': 'N6-methyllysine; by SMYD2; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108971'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22864287'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 372, 'modifier': 'EXACT'}, 'end': {'value': 372, 'modifier': 'EXACT'}}, 'description': 'N6-methyllysine; by SETD7', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15525938'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16415881'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 373, 'modifier': 'EXACT'}, 'end': {'value': 373, 'modifier': 'EXACT'}}, 'description': 'N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20118233'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 373, 'modifier': 'EXACT'}, 'end': {'value': 373, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10656795'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 381, 'modifier': 'EXACT'}, 'end': {'value': 381, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29474172'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19608861'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 382, 'modifier': 'EXACT'}, 'end': {'value': 382, 'modifier': 'EXACT'}}, 'description': 'N6,N6-dimethyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17707234'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20870725'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22864287'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 382, 'modifier': 'EXACT'}, 'end': {'value': 382, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10656795'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15448695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20228809'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23431171'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29681526'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19608861'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 382, 'modifier': 'EXACT'}, 'end': {'value': 382, 'modifier': 'EXACT'}}, 'description': 'N6-methyllysine; by KMT5A; alternate', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17707234'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20870725'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22864287'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 392, 'modifier': 'EXACT'}, 'end': {'value': 392, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CK2, CDK2 and NUAK1', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11239457'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108107'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21317932'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22214662'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '35618207'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 24, 'modifier': 'EXACT'}, 'end': {'value': 24, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21597459'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 291, 'modifier': 'EXACT'}, 'end': {'value': 291, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19536131'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 292, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19536131'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 351, 'modifier': 'EXACT'}, 'end': {'value': 351, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19033443'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 357, 'modifier': 'EXACT'}, 'end': {'value': 357, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19033443'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 386, 'modifier': 'EXACT'}, 'end': {'value': 386, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11124955'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22214662'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.37'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 132, 'modifier': 'EXACT'}}, 'description': 'in isoform 7, isoform 8 and isoform 9', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '16131611'}], 'featureId': 'VSP_040833', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 39, 'modifier': 'EXACT'}}, 'description': 'in isoform 4, isoform 5 and isoform 6', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'featureId': 'VSP_040832', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 332, 'modifier': 'EXACT'}, 'end': {'value': 346, 'modifier': 'EXACT'}}, 'description': 'in isoform 3, isoform 6 and isoform 9', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '16131611'}], 'featureId': 'VSP_040560', 'alternativeSequence': {'originalSequence': 'IRGRERFEMFRELNE', 'alternativeSequences': ['MLLDLRWCYFLINSS']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 332, 'modifier': 'EXACT'}, 'end': {'value': 341, 'modifier': 'EXACT'}}, 'description': 'in isoform 2, isoform 5 and isoform 8', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '16131611'}], 'featureId': 'VSP_006535', 'alternativeSequence': {'originalSequence': 'IRGRERFEMF', 'alternativeSequences': ['DQTSFQKENC']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'in isoform 2, isoform 5 and isoform 8', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '16131611'}], 'featureId': 'VSP_006536', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 347, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'in isoform 3, isoform 6 and isoform 9', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 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'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044550', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 17, 'modifier': 'EXACT'}, 'end': {'value': 17, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044551', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 24, 'modifier': 'EXACT'}, 'end': {'value': 24, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044552', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 28, 'modifier': 'EXACT'}, 'end': {'value': 28, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044553', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 29, 'modifier': 'EXACT'}, 'end': {'value': 30, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047158', 'alternativeSequence': {'originalSequence': 'NN', 'alternativeSequences': ['KD']}}, {'type': 'Natural variant', 'location': {'start': {'value': 31, 'modifier': 'EXACT'}, 'end': {'value': 31, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs201753350', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs201753350'}], 'featureId': 'VAR_044554', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044555', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 34, 'modifier': 'EXACT'}, 'end': {'value': 34, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044556', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 35, 'modifier': 'EXACT'}, 'end': {'value': 35, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs121912661', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912661'}], 'featureId': 'VAR_005852', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 36, 'modifier': 'EXACT'}, 'end': {'value': 36, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs587781866', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587781866'}], 'featureId': 'VAR_044557', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 37, 'modifier': 'EXACT'}, 'end': {'value': 37, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044558', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 37, 'modifier': 'EXACT'}, 'end': {'value': 37, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044559', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 39, 'modifier': 'EXACT'}, 'end': {'value': 39, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044560', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 39, 'modifier': 'EXACT'}, 'end': {'value': 39, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1353016807', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1353016807'}], 'featureId': 'VAR_044561', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 42, 'modifier': 'EXACT'}, 'end': {'value': 42, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044562', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 43, 'modifier': 'EXACT'}, 'end': {'value': 43, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_005853', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 44, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1060501190', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1060501190'}], 'featureId': 'VAR_044563', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 44, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044564', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 44, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044565', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 45, 'modifier': 'EXACT'}, 'end': {'value': 45, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044566', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 46, 'modifier': 'EXACT'}, 'end': {'value': 46, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044567', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 46, 'modifier': 'EXACT'}, 'end': {'value': 46, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs876659630', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs876659630'}], 'featureId': 'VAR_044568', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 47, 'modifier': 'EXACT'}, 'end': {'value': 47, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044569', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 47, 'modifier': 'EXACT'}, 'end': {'value': 47, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs1800371', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1800371'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.12'}], 'featureId': 'VAR_014632', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 48, 'modifier': 'EXACT'}, 'end': {'value': 48, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044570', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 49, 'modifier': 'EXACT'}, 'end': {'value': 49, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587780728', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587780728'}], 'featureId': 'VAR_044571', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 49, 'modifier': 'EXACT'}, 'end': {'value': 49, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs587780728', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587780728'}], 'featureId': 'VAR_044572', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 49, 'modifier': 'EXACT'}, 'end': {'value': 49, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044573', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 52, 'modifier': 'EXACT'}, 'end': {'value': 52, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044574', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 53, 'modifier': 'EXACT'}, 'end': {'value': 53, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005854', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 53, 'modifier': 'EXACT'}, 'end': {'value': 53, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044575', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 54, 'modifier': 'EXACT'}, 'end': {'value': 54, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1555526742', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1555526742'}], 'featureId': 'VAR_044576', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 54, 'modifier': 'EXACT'}, 'end': {'value': 54, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044577', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 56, 'modifier': 'EXACT'}, 'end': {'value': 56, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044578', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 56, 'modifier': 'EXACT'}, 'end': {'value': 56, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044579', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 58, 'modifier': 'EXACT'}, 'end': {'value': 58, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044580', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 58, 'modifier': 'EXACT'}, 'end': {'value': 58, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044581', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 59, 'modifier': 'EXACT'}, 'end': {'value': 59, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1237722021', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1237722021'}], 'featureId': 'VAR_044582', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 59, 'modifier': 'EXACT'}, 'end': {'value': 59, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044583', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 59, 'modifier': 'EXACT'}, 'end': {'value': 59, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045783', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 60, 'modifier': 'EXACT'}, 'end': {'value': 60, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044584', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 60, 'modifier': 'EXACT'}, 'end': {'value': 60, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044585', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 60, 'modifier': 'EXACT'}, 'end': {'value': 60, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_005855', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 61, 'modifier': 'EXACT'}, 'end': {'value': 61, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1460793472', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1460793472'}], 'featureId': 'VAR_044586', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 61, 'modifier': 'EXACT'}, 'end': {'value': 61, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044587', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 62, 'modifier': 'EXACT'}, 'end': {'value': 62, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044588', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 63, 'modifier': 'EXACT'}, 'end': {'value': 63, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs876658902', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs876658902'}], 'featureId': 'VAR_044589', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 63, 'modifier': 'EXACT'}, 'end': {'value': 63, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs372201428', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs372201428'}], 'featureId': 'VAR_044590', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 65, 'modifier': 'EXACT'}, 'end': {'value': 65, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1060501210', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1060501210'}], 'featureId': 'VAR_044591', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['T']}}, {'type': 'Natural 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'location': {'start': {'value': 67, 'modifier': 'EXACT'}, 'end': {'value': 67, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044595', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 67, 'modifier': 'EXACT'}, 'end': {'value': 67, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044596', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 68, 'modifier': 'EXACT'}, 'end': {'value': 68, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044597', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 68, 'modifier': 'EXACT'}, 'end': {'value': 68, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044598', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 69, 'modifier': 'EXACT'}, 'end': {'value': 69, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044599', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 69, 'modifier': 'EXACT'}, 'end': {'value': 69, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs756233241', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs756233241'}], 'featureId': 'VAR_044600', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 69, 'modifier': 'EXACT'}, 'end': {'value': 69, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044601', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 69, 'modifier': 'EXACT'}, 'end': {'value': 69, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs756233241', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs756233241'}], 'featureId': 'VAR_044602', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 70, 'modifier': 'EXACT'}, 'end': {'value': 70, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044603', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 71, 'modifier': 'EXACT'}, 'end': {'value': 71, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044604', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 72, 'modifier': 'EXACT'}, 'end': {'value': 72, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions; dbSNP:rs730882014', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs730882014'}], 'featureId': 'VAR_045784', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 72, 'modifier': 'EXACT'}, 'end': {'value': 72, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045785', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 72, 'modifier': 'EXACT'}, 'end': {'value': 72, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1042522', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1042522'}], 'featureId': 'VAR_045786', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 72, 'modifier': 'EXACT'}, 'end': {'value': 72, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045787', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 72, 'modifier': 'EXACT'}, 'end': {'value': 72, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs1042522', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1042522'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14702039'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16131611'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1999338'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.17'}], 'featureId': 'VAR_005856', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 73, 'modifier': 'EXACT'}, 'end': {'value': 73, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044605', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 73, 'modifier': 'EXACT'}, 'end': {'value': 73, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044606', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 73, 'modifier': 'EXACT'}, 'end': {'value': 73, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782423', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782423'}], 'featureId': 'VAR_044607', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044608', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 75, 'modifier': 'EXACT'}, 'end': {'value': 75, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044609', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 75, 'modifier': 'EXACT'}, 'end': {'value': 75, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044610', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 75, 'modifier': 'EXACT'}, 'end': {'value': 75, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044611', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 76, 'modifier': 'EXACT'}, 'end': {'value': 76, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2946935'}], 'featureId': 'VAR_044612', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 76, 'modifier': 'EXACT'}, 'end': {'value': 76, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044613', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 77, 'modifier': 'EXACT'}, 'end': {'value': 77, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044614', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 78, 'modifier': 'EXACT'}, 'end': {'value': 78, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044615', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 79, 'modifier': 'EXACT'}, 'end': {'value': 79, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044616', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 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{'value': 85, 'modifier': 'EXACT'}, 'end': {'value': 85, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044628', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 86, 'modifier': 'EXACT'}, 'end': {'value': 86, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044629', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 87, 'modifier': 'EXACT'}, 'end': {'value': 87, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005858', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 88, 'modifier': 'EXACT'}, 'end': {'value': 88, 'modifier': 'EXACT'}}, 'description': 'in a sporadic 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'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1423803759'}], 'featureId': 'VAR_044684', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 113, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005863', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 113, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045788', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 113, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044685', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 113, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044686', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 113, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044687', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 113, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587781642', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587781642'}], 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'VAR_044690', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 116, 'modifier': 'EXACT'}, 'end': {'value': 116, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044691', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 117, 'modifier': 'EXACT'}, 'end': {'value': 117, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs755238756', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs755238756'}], 'featureId': 'VAR_044692', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 117, 'modifier': 'EXACT'}, 'end': {'value': 117, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1555526518', 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{'start': {'value': 125, 'modifier': 'EXACT'}, 'end': {'value': 125, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1057520003', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057520003'}], 'featureId': 'VAR_044714', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 125, 'modifier': 'EXACT'}, 'end': {'value': 125, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786201057', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786201057'}], 'featureId': 'VAR_044715', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 126, 'modifier': 'EXACT'}, 'end': {'value': 126, 'modifier': 'EXACT'}}, 'description': 'in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; 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'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005870', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 130, 'modifier': 'EXACT'}, 'end': {'value': 130, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs863224683', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs863224683'}], 'featureId': 'VAR_044734', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 131, 'modifier': 'EXACT'}, 'end': {'value': 131, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044735', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 131, 'modifier': 'EXACT'}, 'end': {'value': 131, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044736', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 131, 'modifier': 'EXACT'}, 'end': {'value': 131, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1131691037', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1131691037'}], 'featureId': 'VAR_044737', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 131, 'modifier': 'EXACT'}, 'end': {'value': 131, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs769270327', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs769270327'}], 'featureId': 'VAR_005872', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 131, 'modifier': 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{'value': 133, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047159', 'alternativeSequence': {'originalSequence': 'KM', 'alternativeSequences': ['NL']}}, {'type': 'Natural variant', 'location': {'start': {'value': 132, 'modifier': 'EXACT'}, 'end': {'value': 132, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs747342068', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs747342068'}], 'featureId': 'VAR_044740', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 132, 'modifier': 'EXACT'}, 'end': {'value': 132, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045790', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 132, 'modifier': 'EXACT'}, 'end': {'value': 132, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519996', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519996'}], 'featureId': 'VAR_005873', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 132, 'modifier': 'EXACT'}, 'end': {'value': 132, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs866775781', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs866775781'}], 'featureId': 'VAR_044741', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 132, 'modifier': 'EXACT'}, 'end': {'value': 132, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs747342068', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 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134, 'modifier': 'EXACT'}, 'end': {'value': 134, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044750', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 134, 'modifier': 'EXACT'}, 'end': {'value': 134, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs267605077', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs267605077'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036504', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 134, 'modifier': 'EXACT'}, 'end': {'value': 134, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044751', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': 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'VAR_047165', 'alternativeSequence': {'originalSequence': 'HM', 'alternativeSequences': ['LI']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044888', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044889', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044890', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044891', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044892', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs867114783', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs867114783'}], 'featureId': 'VAR_005918', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045801', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 168, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044893', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 169, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047166', 'alternativeSequence': {'originalSequence': 'MT', 'alternativeSequences': ['IS']}}, {'type': 'Natural variant', 'location': {'start': {'value': 169, 'modifier': 'EXACT'}, 'end': {'value': 169, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9450901'}], 'featureId': 'VAR_005919', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 169, 'modifier': 'EXACT'}, 'end': {'value': 169, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044894', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 169, 'modifier': 'EXACT'}, 'end': {'value': 169, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005920', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 169, 'modifier': 'EXACT'}, 'end': {'value': 169, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044895', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587780729', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587780729'}], 'featureId': 'VAR_044896', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044897', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs779000871', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs779000871'}], 'featureId': 'VAR_005921', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044898', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005922', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 171, 'modifier': 'EXACT'}, 'end': {'value': 171, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044899', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 171, 'modifier': 'EXACT'}, 'end': {'value': 171, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044900', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 171, 'modifier': 'EXACT'}, 'end': {'value': 171, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044901', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 171, 'modifier': 'EXACT'}, 'end': {'value': 171, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587781845', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587781845'}], 'featureId': 'VAR_044902', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 171, 'modifier': 'EXACT'}, 'end': {'value': 171, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044903', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 171, 'modifier': 'EXACT'}, 'end': {'value': 171, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044904', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 172, 'modifier': 'EXACT'}, 'end': {'value': 172, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005923', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 172, 'modifier': 'EXACT'}, 'end': {'value': 172, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044905', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 172, 'modifier': 'EXACT'}, 'end': {'value': 172, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1131691043', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1131691043'}], 'featureId': 'VAR_044906', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 172, 'modifier': 'EXACT'}, 'end': {'value': 172, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1131691021', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1131691021'}], 'featureId': 'VAR_044907', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 172, 'modifier': 'EXACT'}, 'end': {'value': 172, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044908', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 173, 'modifier': 'EXACT'}, 'end': {'value': 173, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519747', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519747'}], 'featureId': 'VAR_044909', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 173, 'modifier': 'EXACT'}, 'end': {'value': 173, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519747', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519747'}], 'featureId': 'VAR_005924', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 173, 'modifier': 'EXACT'}, 'end': {'value': 173, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519747', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519747'}], 'featureId': 'VAR_044910', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 173, 'modifier': 'EXACT'}, 'end': {'value': 173, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs876660754', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs876660754'}], 'featureId': 'VAR_005925', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 173, 'modifier': 'EXACT'}, 'end': {'value': 173, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs876660754', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs876660754'}], 'featureId': 'VAR_005926', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 173, 'modifier': 'EXACT'}, 'end': {'value': 173, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045802', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 174, 'modifier': 'EXACT'}, 'end': {'value': 174, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs864622115', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs864622115'}], 'featureId': 'VAR_044911', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 174, 'modifier': 'EXACT'}, 'end': {'value': 174, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1064796681', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1064796681'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7682763'}], 'featureId': 'VAR_005927', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 174, 'modifier': 'EXACT'}, 'end': {'value': 174, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044912', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 174, 'modifier': 'EXACT'}, 'end': {'value': 174, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044913', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 174, 'modifier': 'EXACT'}, 'end': {'value': 174, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044914', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 174, 'modifier': 'EXACT'}, 'end': {'value': 174, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044915', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 175, 'modifier': 'EXACT'}, 'end': {'value': 175, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs138729528', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs138729528'}], 'featureId': 'VAR_005928', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 175, 'modifier': 'EXACT'}, 'end': {'value': 175, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs138729528', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs138729528'}], 'featureId': 'VAR_005929', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 175, 'modifier': 'EXACT'}, 'end': {'value': 175, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; reduces interaction with ZNF385A; dbSNP:rs28934578', 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'featureId': 'VAR_005930', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 175, 'modifier': 'EXACT'}, 'end': {'value': 175, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17719541'}], 'featureId': 'VAR_005931', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 175, 'modifier': 'EXACT'}, 'end': {'value': 175, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044916', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 175, 'modifier': 'EXACT'}, 'end': {'value': 175, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044917', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047167', 'alternativeSequence': {'originalSequence': 'CP', 'alternativeSequences': ['FS']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786202962', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786202962'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1394225'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1868473'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8829627'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9450901'}], 'featureId': 'VAR_005933', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044918', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044919', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs967461896', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs967461896'}], 'featureId': 'VAR_044920', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519980', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519980'}], 'featureId': 'VAR_005934', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 176, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786202962', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786202962'}], 'featureId': 'VAR_044921', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044922', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045803', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044923', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045804', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs751477326', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs751477326'}], 'featureId': 'VAR_005935', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs751477326', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs751477326'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036505', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs147002414', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs147002414'}], 'featureId': 'VAR_044924', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044925', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047168', 'alternativeSequence': {'originalSequence': 'HH', 'alternativeSequences': ['QS']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044926', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in a Burkitt lymphoma', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1303181'}], 'featureId': 'VAR_005936', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['HPHP']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044927', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1064795203', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1064795203'}], 'featureId': 'VAR_044928', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1555526004', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1555526004'}], 'featureId': 'VAR_044929', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044930', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044931', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044932', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587780070', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587780070'}], 'featureId': 'VAR_044933', 'alternativeSequence': {'originalSequence': 'H', 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dbSNP:rs1057519991', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519991'}], 'featureId': 'VAR_044936', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs876660821', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs876660821'}], 'featureId': 'VAR_044937', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519991', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519991'}], 'featureId': 'VAR_044938', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['R']}}, {'type': 'Natural 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'modifier': 'EXACT'}, 'end': {'value': 181, 'modifier': 'EXACT'}}, 'description': 'in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation', 'featureId': 'VAR_044949', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 181, 'modifier': 'EXACT'}, 'end': {'value': 181, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782596', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782596'}], 'featureId': 'VAR_044950', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 182, 'modifier': 'EXACT'}, 'end': {'value': 182, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044951', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['R']}}, {'type': 'Natural 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{'start': {'value': 184, 'modifier': 'EXACT'}, 'end': {'value': 184, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs72661117', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs72661117'}], 'featureId': 'VAR_047169', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 184, 'modifier': 'EXACT'}, 'end': {'value': 184, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044957', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 184, 'modifier': 'EXACT'}, 'end': {'value': 184, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005939', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 185, 'modifier': 'EXACT'}, 'end': {'value': 185, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044958', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 185, 'modifier': 'EXACT'}, 'end': {'value': 185, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044959', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 185, 'modifier': 'EXACT'}, 'end': {'value': 185, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044960', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 185, 'modifier': 'EXACT'}, 'end': {'value': 185, 'modifier': 'EXACT'}}, 'description': 'in a sporadic 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'VAR_005941', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 187, 'modifier': 'EXACT'}, 'end': {'value': 187, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044969', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 187, 'modifier': 'EXACT'}, 'end': {'value': 187, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045805', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 187, 'modifier': 'EXACT'}, 'end': {'value': 187, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044970', 'alternativeSequence': {'originalSequence': 'G', 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'Natural variant', 'location': {'start': {'value': 189, 'modifier': 'EXACT'}, 'end': {'value': 189, 'modifier': 'EXACT'}}, 'description': 'in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912665', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912665'}], 'featureId': 'VAR_044978', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 190, 'modifier': 'EXACT'}, 'end': {'value': 190, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_044979', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 190, 'modifier': 'EXACT'}, 'end': {'value': 190, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_044980', 'alternativeSequence': {'originalSequence': 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191, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587778718', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587778718'}], 'featureId': 'VAR_044985', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 191, 'modifier': 'EXACT'}, 'end': {'value': 191, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587778718', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587778718'}], 'featureId': 'VAR_044986', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 191, 'modifier': 'EXACT'}, 'end': {'value': 191, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs868590738', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs868590738'}], 'featureId': 'VAR_044987', 'alternativeSequence': 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'VAR_045051', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 207, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045052', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 207, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045053', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 207, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs923100890', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs923100890'}], 'featureId': 'VAR_045054', 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'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587778720'}], 'featureId': 'VAR_005955', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045086', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 214, 'modifier': 'EXACT'}, 'end': {'value': 214, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045087', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 214, 'modifier': 'EXACT'}, 'end': {'value': 214, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1057519992', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519992'}], 'featureId': 'VAR_045088', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 214, 'modifier': 'EXACT'}, 'end': {'value': 214, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587781386', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587781386'}], 'featureId': 'VAR_047177', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 214, 'modifier': 'EXACT'}, 'end': {'value': 214, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519992', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519992'}], 'featureId': 'VAR_045089', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': 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{'value': 215, 'modifier': 'EXACT'}, 'end': {'value': 215, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782177', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782177'}], 'featureId': 'VAR_045093', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 215, 'modifier': 'EXACT'}, 'end': {'value': 215, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045810', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 215, 'modifier': 'EXACT'}, 'end': {'value': 215, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782177', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782177'}], 'featureId': 'VAR_045094', 'alternativeSequence': 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variant', 'location': {'start': {'value': 218, 'modifier': 'EXACT'}, 'end': {'value': 218, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045106', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 218, 'modifier': 'EXACT'}, 'end': {'value': 218, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045107', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 218, 'modifier': 'EXACT'}, 'end': {'value': 218, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1555525743', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1555525743'}], 'featureId': 'VAR_045108', 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 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238, 'modifier': 'EXACT'}, 'end': {'value': 238, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs730882005', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs730882005'}], 'featureId': 'VAR_005966', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 238, 'modifier': 'EXACT'}, 'end': {'value': 238, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057519981', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519981'}], 'featureId': 'VAR_045200', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 238, 'modifier': 'EXACT'}, 'end': {'value': 238, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045850', 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[{'database': 'dbSNP', 'id': 'rs28934573'}], 'featureId': 'VAR_045217', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 241, 'modifier': 'EXACT'}, 'end': {'value': 241, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs28934573'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1699228'}], 'featureId': 'VAR_005969', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 241, 'modifier': 'EXACT'}, 'end': {'value': 241, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057520002', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 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'description': 'in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912655', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912655'}], 'featureId': 'VAR_045224', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047184', 'alternativeSequence': {'originalSequence': 'MG', 'alternativeSequences': ['IC']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047185', 'alternativeSequence': {'originalSequence': 'MG', 'alternativeSequences': ['IS']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045225', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045226', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786203117', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786203117'}], 'featureId': 'VAR_045227', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045228', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs730882006', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs730882006'}], 'featureId': 'VAR_045229', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 243, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786203117', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786203117'}], 'featureId': 'VAR_045230', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs985033810', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs985033810'}], 'featureId': 'VAR_047186', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519989', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519989'}], 'featureId': 'VAR_045231', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057517983', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057517983'}], 'featureId': 'VAR_045232', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045233', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519989', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519989'}], 'featureId': 'VAR_045234', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1057519989', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1057519989'}], 'featureId': 'VAR_045235', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 244, 'modifier': 'EXACT'}, 'end': {'value': 244, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs985033810', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs985033810'}], 'featureId': 'VAR_045236', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs121912656', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912656'}], 'featureId': 'VAR_005971', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs28934575'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1394225'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1978757'}], 'featureId': 'VAR_005972', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912656', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912656'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2259385'}], 'featureId': 'VAR_005973', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045237', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045851', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045852', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045853', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045854', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs28934575', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs28934575'}], 'featureId': 'VAR_045238', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs28934575'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8829627'}], 'featureId': 'VAR_005974', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912656', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912656'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2263646'}], 'featureId': 'VAR_005975', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 246, 'modifier': 'EXACT'}, 'end': {'value': 246, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1019340046', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1019340046'}], 'featureId': 'VAR_045239', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 246, 'modifier': 'EXACT'}, 'end': {'value': 246, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045240', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 246, 'modifier': 'EXACT'}, 'end': {'value': 246, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs483352695', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs483352695'}], 'featureId': 'VAR_044020', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 246, 'modifier': 'EXACT'}, 'end': {'value': 246, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587780074', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587780074'}], 'featureId': 'VAR_005976', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 246, 'modifier': 'EXACT'}, 'end': {'value': 246, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587780074', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587780074'}], 'featureId': 'VAR_005977', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 246, 'modifier': 'EXACT'}, 'end': {'value': 246, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs483352695', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs483352695'}], 'featureId': 'VAR_005978', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047187', 'alternativeSequence': {'originalSequence': 'NR', 'alternativeSequences': ['IP']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_047188', 'alternativeSequence': {'originalSequence': 'NR', 'alternativeSequences': ['KW']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1452189221', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1452189221'}], 'featureId': 'VAR_045241', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045855', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786201762', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786201762'}], 'featureId': 'VAR_005980', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045242', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs786201762', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs786201762'}], 'featureId': 'VAR_045243', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_047189', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 247, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045244', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045245', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs121912651', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912651'}], 'featureId': 'VAR_005981', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs11540652', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs11540652'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1394225'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7682763'}], 'featureId': 'VAR_005982', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs11540652', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs11540652'}], 'featureId': 'VAR_045246', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs11540652'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2263646'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7682763'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7887414'}], 'featureId': 'VAR_005983', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912651', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912651'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1978757'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '27657329'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8829627'}], 'featureId': 'VAR_005984', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047190', 'alternativeSequence': {'originalSequence': 'RP', 'alternativeSequences': ['SA']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_047191', 'alternativeSequence': {'originalSequence': 'RP', 'alternativeSequences': ['SS']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782082', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782082'}], 'featureId': 'VAR_005985', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045247', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782329', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782329'}], 'featureId': 'VAR_045248', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782329', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782329'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17224074'}], 'featureId': 'VAR_033037', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045856', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs28934571', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs28934571'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1694291'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20385133'}], 'featureId': 'VAR_005986', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782329', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782329'}], 'featureId': 'VAR_045249', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 249, 'modifier': 'EXACT'}, 'end': {'value': 249, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs587782082', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782082'}], 'featureId': 'VAR_045250', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045251', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045857', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045252', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1064794311', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1064794311'}], 'featureId': 'VAR_047192', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045858', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045253', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045254', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045255', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 251, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045256', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 251, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs730882007', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs730882007'}], 'featureId': 'VAR_045257', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 251, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation; dbSNP:rs878854074', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs878854074'}], 'featureId': 'VAR_045258', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['M']}}, {'type': 'Natural variant', 'location': {'start': {'value': 251, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_005987', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['N']}}, {'type': 'Natural variant', 'location': {'start': {'value': 251, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs730882027', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs730882027'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17224074'}], 'featureId': 'VAR_033038', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 251, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 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[{'database': 'dbSNP', 'id': 'rs763098116'}], 'featureId': 'VAR_045375', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs17849781', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs17849781'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15489334'}], 'featureId': 'VAR_006001', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045869', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': 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cancer; somatic mutation', 'featureId': 'VAR_045514', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 323, 'modifier': 'EXACT'}, 'end': {'value': 323, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1432281680', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1432281680'}], 'featureId': 'VAR_047211', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 324, 'modifier': 'EXACT'}, 'end': {'value': 324, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045515', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 324, 'modifier': 'EXACT'}, 'end': {'value': 324, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions', 'featureId': 'VAR_045875', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 324, 'modifier': 'EXACT'}, 'end': {'value': 324, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045516', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 325, 'modifier': 'EXACT'}, 'end': {'value': 325, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045517', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 325, 'modifier': 'EXACT'}, 'end': {'value': 325, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045518', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 325, 'modifier': 'EXACT'}, 'end': {'value': 325, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation; dbSNP:rs121912659', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912659'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1565144'}], 'featureId': 'VAR_006039', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 326, 'modifier': 'EXACT'}, 'end': {'value': 326, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045519', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 327, 'modifier': 'EXACT'}, 'end': {'value': 327, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045520', 'alternativeSequence': {'originalSequence': 'Y', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 327, 'modifier': 'EXACT'}, 'end': {'value': 327, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045521', 'alternativeSequence': {'originalSequence': 'Y', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 328, 'modifier': 'EXACT'}, 'end': {'value': 328, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045522', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 328, 'modifier': 'EXACT'}, 'end': {'value': 328, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045523', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 328, 'modifier': 'EXACT'}, 'end': {'value': 328, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045524', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 329, 'modifier': 'EXACT'}, 'end': {'value': 329, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs969930693', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs969930693'}], 'featureId': 'VAR_045525', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 329, 'modifier': 'EXACT'}, 'end': {'value': 329, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045526', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 330, 'modifier': 'EXACT'}, 'end': {'value': 330, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045527', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 330, 'modifier': 'EXACT'}, 'end': {'value': 330, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047212', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 330, 'modifier': 'EXACT'}, 'end': {'value': 330, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045528', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 331, 'modifier': 'EXACT'}, 'end': {'value': 331, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs11575996', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs11575996'}], 'featureId': 'VAR_045529', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 331, 'modifier': 'EXACT'}, 'end': {'value': 331, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045530', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 331, 'modifier': 'EXACT'}, 'end': {'value': 331, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs1064795056', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1064795056'}], 'featureId': 'VAR_045531', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 332, 'modifier': 'EXACT'}, 'end': {'value': 332, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045532', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 334, 'modifier': 'EXACT'}, 'end': {'value': 334, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_006040', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 334, 'modifier': 'EXACT'}, 'end': {'value': 334, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs730882028', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs730882028'}], 'featureId': 'VAR_045533', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 335, 'modifier': 'EXACT'}, 'end': {'value': 335, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045534', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 335, 'modifier': 'EXACT'}, 'end': {'value': 335, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs771939956', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs771939956'}], 'featureId': 'VAR_045535', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 335, 'modifier': 'EXACT'}, 'end': {'value': 335, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045536', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs587782529', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782529'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9452042'}], 'featureId': 'VAR_006041', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912664', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912664'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11481490'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}], 'featureId': 'VAR_035016', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs121912664', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912664'}], 'featureId': 'VAR_045537', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912664', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912664'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}], 'featureId': 'VAR_045538', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 338, 'modifier': 'EXACT'}, 'end': {'value': 338, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045539', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 338, 'modifier': 'EXACT'}, 'end': {'value': 338, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs150293825', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs150293825'}], 'featureId': 'VAR_045540', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 339, 'modifier': 'EXACT'}, 'end': {'value': 339, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs17882252', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs17882252'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.12'}], 'featureId': 'VAR_022316', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 339, 'modifier': 'EXACT'}, 'end': {'value': 339, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs17882252', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs17882252'}], 'featureId': 'VAR_045541', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 341, 'modifier': 'EXACT'}, 'end': {'value': 341, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045542', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045543', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs375338359', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs375338359'}], 'featureId': 'VAR_045544', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs375338359', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs375338359'}], 'featureId': 'VAR_047213', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 343, 'modifier': 'EXACT'}, 'end': {'value': 343, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045545', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 344, 'modifier': 'EXACT'}, 'end': {'value': 344, 'modifier': 'EXACT'}}, 'description': 'in LFS; germline mutation and in a sporadic cancer; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912662', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs121912662'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '36108750'}], 'featureId': 'VAR_045546', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 344, 'modifier': 'EXACT'}, 'end': {'value': 344, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045547', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 346, 'modifier': 'EXACT'}, 'end': {'value': 346, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045548', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 347, 'modifier': 'EXACT'}, 'end': {'value': 347, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045549', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 347, 'modifier': 'EXACT'}, 'end': {'value': 347, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation', 'featureId': 'VAR_045550', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 348, 'modifier': 'EXACT'}, 'end': {'value': 348, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045551', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 348, 'modifier': 'EXACT'}, 'end': {'value': 348, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045552', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 349, 'modifier': 'EXACT'}, 'end': {'value': 349, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045553', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 352, 'modifier': 'EXACT'}, 'end': {'value': 352, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045554', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 353, 'modifier': 'EXACT'}, 'end': {'value': 353, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045555', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 354, 'modifier': 'EXACT'}, 'end': {'value': 354, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045556', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 354, 'modifier': 'EXACT'}, 'end': {'value': 354, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs755394212', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs755394212'}], 'featureId': 'VAR_045557', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 354, 'modifier': 'EXACT'}, 'end': {'value': 354, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs752142489', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs752142489'}], 'featureId': 'VAR_047214', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 356, 'modifier': 'EXACT'}, 'end': {'value': 356, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045558', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 356, 'modifier': 'EXACT'}, 'end': {'value': 356, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045559', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 358, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045560', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['D']}}, {'type': 'Natural variant', 'location': {'start': {'value': 358, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs587782237', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587782237'}], 'featureId': 'VAR_045561', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 360, 'modifier': 'EXACT'}, 'end': {'value': 360, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs35993958', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs35993958'}], 'featureId': 'VAR_045562', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 360, 'modifier': 'EXACT'}, 'end': {'value': 360, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs35993958', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs35993958'}], 'featureId': 'VAR_045563', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 363, 'modifier': 'EXACT'}, 'end': {'value': 363, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs876660285', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs876660285'}], 'featureId': 'VAR_045564', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 364, 'modifier': 'EXACT'}, 'end': {'value': 364, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045565', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 364, 'modifier': 'EXACT'}, 'end': {'value': 364, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045566', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 364, 'modifier': 'EXACT'}, 'end': {'value': 364, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045567', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 365, 'modifier': 'EXACT'}, 'end': {'value': 365, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_047215', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 365, 'modifier': 'EXACT'}, 'end': {'value': 365, 'modifier': 'EXACT'}}, 'description': 'in a familial cancer not matching LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs267605075', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs267605075'}], 'featureId': 'VAR_045568', 'alternativeSequence': {'originalSequence': 'H', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 366, 'modifier': 'EXACT'}, 'end': {'value': 366, 'modifier': 'EXACT'}}, 'description': 'in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17881470', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs17881470'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.12'}], 'featureId': 'VAR_022317', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 370, 'modifier': 'EXACT'}, 'end': {'value': 370, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045569', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['Q']}}, {'type': 'Natural variant', 'location': {'start': {'value': 376, 'modifier': 'EXACT'}, 'end': {'value': 376, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045570', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Natural variant', 'location': {'start': {'value': 376, 'modifier': 'EXACT'}, 'end': {'value': 376, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045571', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 379, 'modifier': 'EXACT'}, 'end': {'value': 379, 'modifier': 'EXACT'}}, 'description': 'in sporadic cancers; somatic mutation; dbSNP:rs863224682', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs863224682'}], 'featureId': 'VAR_045572', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 385, 'modifier': 'EXACT'}, 'end': {'value': 385, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs1555524094', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs1555524094'}], 'featureId': 'VAR_045573', 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 389, 'modifier': 'EXACT'}, 'end': {'value': 389, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation; dbSNP:rs587783064', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs587783064'}], 'featureId': 'VAR_045574', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 392, 'modifier': 'EXACT'}, 'end': {'value': 392, 'modifier': 'EXACT'}}, 'description': 'in a sporadic cancer; somatic mutation', 'featureId': 'VAR_045575', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 15, 'modifier': 'EXACT'}, 'end': {'value': 15, 'modifier': 'EXACT'}}, 'description': 'Loss of interaction with PPP2R5C, PPP2CAANDPPP2R1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17967874'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 18, 'modifier': 'EXACT'}, 'end': {'value': 18, 'modifier': 'EXACT'}}, 'description': 'No effect on interaction with MDM2 and increase in protein levels after DNA damage.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 20, 'modifier': 'EXACT'}, 'end': {'value': 20, 'modifier': 'EXACT'}}, 'description': 'Abolishes phosphorylation site. Abolishes increase in protein levels after DNA damage.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 20, 'modifier': 'EXACT'}, 'end': {'value': 20, 'modifier': 'EXACT'}}, 'description': 'Constitutively increased TP53 protein levels.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 22, 'modifier': 'EXACT'}, 'end': {'value': 23, 'modifier': 'EXACT'}}, 'description': 'Loss of interaction with MDM2, leading to constitutively increased TP53 protein levels.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10570149'}], 'alternativeSequence': {'originalSequence': 'LW', 'alternativeSequences': ['QS']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 24, 'modifier': 'EXACT'}, 'end': {'value': 24, 'modifier': 'EXACT'}}, 'description': 'Abolishes ubiquitination by MUL1.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21597459'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 37, 'modifier': 'EXACT'}, 'end': {'value': 37, 'modifier': 'EXACT'}}, 'description': 'Abolishes phosphorylation by MAPKAPK5.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17254968'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 46, 'modifier': 'EXACT'}, 'end': {'value': 46, 'modifier': 'EXACT'}}, 'description': 'Abolishes phosphorylation by DYRK2 and HIPK2 and acetylation of K-382 by CREBBP.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11740489'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16219768'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17349958'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 46, 'modifier': 'EXACT'}, 'end': {'value': 46, 'modifier': 'EXACT'}}, 'description': 'Alters interaction with WWOX.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11740489'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16219768'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17349958'}], 'alternativeSequence': {}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 55, 'modifier': 'EXACT'}, 'end': {'value': 55, 'modifier': 'EXACT'}}, 'description': 'Blocks phosphorylation by TAF1.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15053879'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 183, 'modifier': 'EXACT'}, 'end': {'value': 183, 'modifier': 'EXACT'}}, 'description': 'Abolishes strongly phosphorylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 183, 'modifier': 'EXACT'}, 'end': {'value': 183, 'modifier': 'EXACT'}}, 'description': 'Inhibits slightly its transcriptional activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['E']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 248, 'modifier': 'EXACT'}, 'end': {'value': 248, 'modifier': 'EXACT'}}, 'description': 'Does not induce SNAI1 degradation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20385133'}], 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['S']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 269, 'modifier': 'EXACT'}, 'end': {'value': 269, 'modifier': 'EXACT'}}, 'description': 'Abolishes phosphorylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 269, 'modifier': 'EXACT'}, 'end': {'value': 269, 'modifier': 'EXACT'}}, 'description': 'Inhibits strongly its transcriptional activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['E']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 284, 'modifier': 'EXACT'}, 'end': {'value': 284, 'modifier': 'EXACT'}}, 'description': 'Inhibits strongly its transcriptional activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20959462'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['E']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 291, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': 'Abolishes polyubiquitination by MKRN1.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19536131'}], 'alternativeSequence': {'originalSequence': 'KK', 'alternativeSequences': ['RR']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 319, 'modifier': 'EXACT'}, 'end': {'value': 319, 'modifier': 'EXACT'}}, 'description': 'Loss of nuclear localization; when associated with A-320 and A-321.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2156209'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 320, 'modifier': 'EXACT'}, 'end': {'value': 320, 'modifier': 'EXACT'}}, 'description': 'Loss of nuclear localization; when associated with A-319 and A-321.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2156209'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 321, 'modifier': 'EXACT'}, 'end': {'value': 321, 'modifier': 'EXACT'}}, 'description': 'Loss of nuclear localization; when associated with A-319 and A-320.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '2156209'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 333, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'Reduced methylation by PRMT5. Reduced nuclear localization. Decreased binding to promoters of target genes. Reduced transcriptional activity. Decrease in cell cycle arrest.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19011621'}], 'alternativeSequence': {'originalSequence': 'RGRER', 'alternativeSequences': ['KGKEK']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 359, 'modifier': 'EXACT'}, 'end': {'value': 359, 'modifier': 'EXACT'}}, 'description': 'Abolishes binding to USP7.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16402859'}], 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 361, 'modifier': 'EXACT'}, 'end': {'value': 361, 'modifier': 'EXACT'}}, 'description': 'Abolishes binding to USP7.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16402859'}], 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['E']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 362, 'modifier': 'EXACT'}, 'end': {'value': 362, 'modifier': 'EXACT'}}, 'description': 'Abolishes binding to USP7.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16402859'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 370, 'modifier': 'EXACT'}, 'end': {'value': 370, 'modifier': 'EXACT'}}, 'description': 'Induces a decrease in methylation by SMYD2.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17108971'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 372, 'modifier': 'EXACT'}, 'end': {'value': 372, 'modifier': 'EXACT'}}, 'description': 'Induces a decrease in protein stabilization.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15525938'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 373, 'modifier': 'EXACT'}, 'end': {'value': 373, 'modifier': 'EXACT'}}, 'description': 'Abolishes dimethylation by EHMT1 and EHMT2.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20118233'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 381, 'modifier': 'EXACT'}, 'end': {'value': 381, 'modifier': 'EXACT'}}, 'description': 'Mimics acetylation, leading to increased stability.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29474172'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['Q']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 381, 'modifier': 'EXACT'}, 'end': {'value': 381, 'modifier': 'EXACT'}}, 'description': 'Decreased acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29474172'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 382, 'modifier': 'EXACT'}, 'end': {'value': 382, 'modifier': 'EXACT'}}, 'description': 'Abolishes acetylation by CREBBP.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11740489'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17707234'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20870725'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 382, 'modifier': 'EXACT'}, 'end': {'value': 382, 'modifier': 'EXACT'}}, 'description': 'Abolishes monomethylation by KMT5A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11740489'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17707234'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20870725'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 383, 'modifier': 'EXACT'}, 'end': {'value': 383, 'modifier': 'EXACT'}}, 'description': 'Abolishes S-315 phosphorylation by CDK2/cyclin A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}], 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 385, 'modifier': 'EXACT'}, 'end': {'value': 385, 'modifier': 'EXACT'}}, 'description': 'Reduced SUMO1 conjugation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10884347'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11124955'}], 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 386, 'modifier': 'EXACT'}, 'end': {'value': 386, 'modifier': 'EXACT'}}, 'description': 'Abolishes SUMO1 conjugation, in vitro and in vivo.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11124955'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.37'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 387, 'modifier': 'EXACT'}, 'end': {'value': 387, 'modifier': 'EXACT'}}, 'description': 'No effect SUMO1 conjugation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11124955'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 388, 'modifier': 'EXACT'}, 'end': {'value': 388, 'modifier': 'EXACT'}}, 'description': 'Abolishes SUMO1 conjugation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11124955'}], 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 392, 'modifier': 'EXACT'}, 'end': {'value': 392, 'modifier': 'EXACT'}}, 'description': 'Mimics phosphorylation; promotes ability to undergo liquid-liquid phase separation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '35618207'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 392, 'modifier': 'EXACT'}, 'end': {'value': 392, 'modifier': 'EXACT'}}, 'description': 'Abolished ability to undergo liquid-liquid phase separation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '31953488'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['E']}}, {'type': 'Helix', 'location': {'start': {'value': 3, 'modifier': 'EXACT'}, 'end': {'value': 6, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5HOU'}]}, {'type': 'Turn', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 10, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5HOU'}]}, {'type': 'Helix', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 29, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '9C5S'}]}, {'type': 'Helix', 'location': {'start': {'value': 30, 'modifier': 'EXACT'}, 'end': {'value': 32, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5HPD'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 35, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '2L14'}]}, {'type': 'Helix', 'location': {'start': {'value': 36, 'modifier': 'EXACT'}, 'end': {'value': 38, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '2B3G'}]}, {'type': 'Helix', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '2B3G'}]}, {'type': 'Helix', 'location': {'start': {'value': 47, 'modifier': 'EXACT'}, 'end': {'value': 55, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '2B3G'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 95, 'modifier': 'EXACT'}, 'end': {'value': 97, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '7B49'}]}, {'type': 'Turn', 'location': {'start': {'value': 105, 'modifier': 'EXACT'}, 'end': {'value': 108, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 110, 'modifier': 'EXACT'}, 'end': {'value': 112, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 118, 'modifier': 'EXACT'}, 'end': {'value': 120, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3Q05'}]}, {'type': 'Turn', 'location': {'start': {'value': 121, 'modifier': 'EXACT'}, 'end': {'value': 123, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3Q05'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 124, 'modifier': 'EXACT'}, 'end': {'value': 127, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Turn', 'location': {'start': {'value': 128, 'modifier': 'EXACT'}, 'end': {'value': 131, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 132, 'modifier': 'EXACT'}, 'end': {'value': 135, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 141, 'modifier': 'EXACT'}, 'end': {'value': 146, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 148, 'modifier': 'EXACT'}, 'end': {'value': 150, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5UN8'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 156, 'modifier': 'EXACT'}, 'end': {'value': 165, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Helix', 'location': {'start': {'value': 166, 'modifier': 'EXACT'}, 'end': {'value': 168, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Helix', 'location': {'start': {'value': 177, 'modifier': 'EXACT'}, 'end': {'value': 180, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 181, 'modifier': 'EXACT'}, 'end': {'value': 183, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '4KVP'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 187, 'modifier': 'EXACT'}, 'end': {'value': 189, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6GGC'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 194, 'modifier': 'EXACT'}, 'end': {'value': 199, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 207, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Turn', 'location': {'start': {'value': 209, 'modifier': 'EXACT'}, 'end': {'value': 211, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 214, 'modifier': 'EXACT'}, 'end': {'value': 219, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '3D06'}]}, {'type': 'Turn', 'location': {'start': {'value': 225, 'modifier': 'EXACT'}, 'end': {'value': 227, 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